MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Birth length |
0.0601 |
0.0194 |
0.00198 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0163 |
0.00537 |
0.00233 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
34.2 |
13.3 |
0.00998 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gout |
-0.128 |
0.0501 |
0.0108 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I84 Haemorrhoids |
-0.0937 |
0.0371 |
0.0115 |
Wald ratio |
1 |
cis |
NA |
| Ovarian cancer |
0.0758 |
0.031 |
0.0144 |
Wald ratio |
1 |
cis |
NA |
| Invasive mucinous ovarian cancer |
0.23 |
0.0952 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0106 |
0.00454 |
0.019 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R55 Syncope and collapse |
0.109 |
0.05 |
0.0299 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.0115 |
0.00537 |
0.0324 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
0.0197 |
0.00922 |
0.0328 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.00857 |
0.0041 |
0.0368 |
Wald ratio |
1 |
cis |
NA |
| …and 97 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4541_49_2 |
CDON |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
36 association rows across 26 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Cell adhesion molecule-related/down-regulated by oncogenes l |
1e-352 |
rs201453301 |
4 |
GCST90246968 |
no MR -> candidate analysis |
| Height |
5e-142 |
rs519781 |
3 |
GCST90245848 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CDON levels |
1e-92 |
rs77550118 |
1 |
GCST90944181 |
no MR -> candidate analysis |
| Cell adhesion molecule-related/down-regulated by oncogenes l |
4e-86 |
rs562022020 |
1 |
GCST90240654 |
no MR -> candidate analysis |
| Serum levels of protein CDON |
2e-80 |
rs78196034 |
1 |
GCST90088726 |
no MR -> candidate analysis |
| Blood protein levels |
2e-48 |
rs60929339 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Circulating CDON levels |
8e-46 |
rs3737336 |
4 |
GCST90860624 |
no MR -> candidate analysis |
| CDON protein levels |
1e-35 |
rs577890875 |
2 |
GCST90468687 |
no MR -> candidate analysis |
| GLIPR1 protein levels |
2e-19 |
rs755994258 |
1 |
GCST90469357 |
no MR -> candidate analysis |
| Cell adhesion molecule-related/down-regulated by oncogenes l |
1e-17 |
rs11826465 |
1 |
GCST90237674 |
no MR -> candidate analysis |
| Circulating DPEP1 levels |
3e-13 |
rs616806 |
1 |
GCST90860743 |
no MR -> candidate analysis |
| Height (baseline) |
6e-12 |
rs3016445 |
1 |
GCST90565843 |
no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
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|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2124 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| holoprosencephaly |
0.89 |
— |
established (curated) |
no MR -> candidate analysis |
| pituitary stalk interruption syndrome |
0.598 |
— |
established (curated) |
no MR -> candidate analysis |
| alobar holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| microform holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| septopreoptic holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| semilobar holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| lobar holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| midline interhemispheric variant of holoprosencephaly |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| coloboma |
0.426 |
— |
established (curated) |
no MR -> candidate analysis |
| benign thyroid gland neoplasm |
0.389 |
— |
common-variant locus |
no MR -> candidate analysis |
| hereditary disease |
0.318 |
— |
established (curated) |
no MR -> candidate analysis |
| Intellectual disability |
0.245 |
— |
established (curated) |
no MR -> candidate analysis |
| alcohol drinking |
0.232 |
— |
common-variant locus |
no MR -> candidate analysis |
| auditory system disorder |
0.232 |
— |
common-variant locus |
no MR -> candidate analysis |
| bronchial disorder |
0.2 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1e-13, LOEUF=0.734 — LoF-tolerant |
| GWAS Catalog |
74 unique SNPs / 148 rows |
| ClinVar |
895 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2124 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CDON’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 895 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 36 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q4KMG0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000064309/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CDON — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CDON — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CDON%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CDON — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:45:55 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none