MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Creatinine (enzymatic) in urine | -0.0295 | 0.0108 | 0.00648 | Wald ratio | 1 | trans | NA |
| Mean cell haemoglobin concentration | 0.0427 | 0.0161 | 0.008 | Wald ratio | 1 | trans | NA |
| IgA nephropathy | 1.05 | 0.396 | 0.0082 | Wald ratio | 1 | trans | NA |
| Serum cystatin C (eGFRcys) | 0.0224 | 0.00874 | 0.0105 | Wald ratio | 1 | trans | NA |
| Serum creatinine (eGFRcrea) | 0.00979 | 0.00385 | 0.0109 | Wald ratio | 1 | trans | NA |
| Urinary albumin-to-creatinine ratio | 0.0699 | 0.028 | 0.0124 | Wald ratio | 1 | trans | NA |
| Triglycerides | -0.0517 | 0.021 | 0.0136 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | -0.341 | 0.141 | 0.0153 | Wald ratio | 1 | trans | NA |
| Fasting glucose | -0.0318 | 0.014 | 0.0229 | Wald ratio | 1 | trans | NA |
| Femoral neck bone mineral density | -0.0737 | 0.0348 | 0.0343 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.132 | 0.0627 | 0.0356 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: osteoarthritis | -0.0859 | 0.0414 | 0.0378 | Wald ratio | 1 | trans | NA |
| …and 113 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
10 association rows across 7 traits (6 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Red blood cell erythrocyte count (UKB data field 30010) | 3e-12 | rs370728588 | 1 | GCST90468098 | no MR -> candidate analysis |
| Corpus callosum posterior volume | 8e-9 | rs751410660 | 1 | GCST90281348 | no MR -> candidate analysis |
| Corpus callosum posterior subregion volume | 1e-8 | rs7674765 | 2 | GCST90728575 | no MR -> candidate analysis |
| Odor identification (fish) | 4e-8 | rs73252922 | 1 | GCST90628027 | no MR -> candidate analysis |
| Total corpus callosum volume | 4e-8 | rs10033247 | 1 | GCST90728576 | no MR -> candidate analysis |
| Post bronchodilator FEV1/FVC ratio | 1e-6 | rs192046469 | 3 | GCST003264 | no MR -> candidate analysis |
| Pregnancy loss in nulliparas | 2e-6 | rs60907021 | 1 | GCST90429686 | no MR -> candidate analysis |
No genetically-associated diseases retrieved from Open Targets.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.007, LOEUF=0.847 — LoF-tolerant |
| GWAS Catalog | 51 unique SNPs / 94 rows |
| ClinVar | 39 records; 8 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 361 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CHIC2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 39 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 7 of 7 traits by best p-value, aggregated from 10 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9UKJ5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000109220/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CHIC2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CHIC2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CHIC2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CHIC2 — GWAS Catalog search API (live; release not exposed)