Protein Dossier — CLEC11A (C-type lectin domain family 11 member A)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: K40 Inguinal hernia |
0.292 |
0.082 |
3.67e-04 |
Wald ratio |
1 |
cis |
NA |
| Ovarian cancer |
0.28 |
0.101 |
0.00568 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
0.534 |
0.22 |
0.0151 |
Wald ratio |
1 |
cis |
NA |
| Putamen volume |
113 |
46.9 |
0.0155 |
Wald ratio |
1 |
cis |
NA |
| High grade serous ovarian cancer |
0.27 |
0.12 |
0.0243 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.297 |
0.142 |
0.0358 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
0.0519 |
0.026 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin concentration |
0.0513 |
0.026 |
0.0483 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.16 |
0.0818 |
0.0499 |
Wald ratio |
1 |
cis |
NA |
| Weight |
-0.0303 |
0.0157 |
0.0545 |
Wald ratio |
1 |
cis |
NA |
| Clear cell ovarian cancer |
0.58 |
0.307 |
0.0591 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting |
0.381 |
0.204 |
0.0616 |
Wald ratio |
1 |
cis |
NA |
| …and 80 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2966_65_2 |
SCGF-beta |
Suhre K |
2019 |
prot-c-4500_50_2 |
SCGF-alpha |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
39 association rows across 18 traits (35 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CLEC11A levels |
7e-404 |
rs141369989 |
5 |
GCST90860601 |
no MR -> candidate analysis |
| CLEC11A protein levels |
2e-184 |
rs562569155 |
3 |
GCST90468764 |
no MR -> candidate analysis |
| Stem Cell Growth Factor-alpha levels |
1e-177 |
rs116924815 |
4 |
GCST90249448 |
no MR -> candidate analysis |
| Stem Cell Growth Factor-beta levels |
9e-149 |
rs116924815 |
5 |
GCST90249449 |
no MR -> candidate analysis |
| KLK15 protein levels |
2e-63 |
rs8104100 |
2 |
GCST90469701 |
no MR -> candidate analysis |
| Serum levels of protein CLEC11A |
9e-37 |
rs142930583 |
3 |
GCST90088721 |
no MR -> candidate analysis |
| Stem Cell Growth Factor-beta levels (CLEC11A.2966.65.2) |
2e-16 |
rs182722517 |
1 |
GCST90242896 |
no MR -> candidate analysis |
| Stem cell growth factor beta levels |
2e-16 |
rs116924815 |
1 |
GCST004428 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein CLEC11A levels |
3e-15 |
rs11084024 |
1 |
GCST90944712 |
no MR -> candidate analysis |
| Height |
9e-15 |
rs562569155 |
5 |
GCST90025949 |
no MR -> candidate analysis |
| Standing height (UKB data field 50) |
2e-12 |
rs562569155 |
1 |
GCST90468178 |
no MR -> candidate analysis |
| Blood protein levels |
4e-9 |
rs13866 |
2 |
GCST006585 |
no MR -> candidate analysis |
| …and 6 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=7.3e-13, LOEUF=1.37 — LoF-tolerant |
| GWAS Catalog |
61 unique SNPs / 122 rows |
| ClinVar |
80 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 517 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CLEC11A’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 80 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 39 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9Y240 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000105472/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CLEC11A — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CLEC11A — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CLEC11A%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CLEC11A — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:52:19 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none