MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Eye problems or disorders: Diabetes related eye disease | 0.0782 | 0.0236 | 9.22e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.0459 | 0.0153 | 0.00263 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries | 0.0514 | 0.0223 | 0.0215 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.0216 | 0.00983 | 0.0281 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | 0.018 | 0.0087 | 0.0383 | Wald ratio | 1 | cis | NA |
| Hip osteoarthritis | 0.0465 | 0.0231 | 0.0439 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: ankylosing spondylitis | -0.0782 | 0.0408 | 0.0553 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | -0.065 | 0.0341 | 0.0563 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | -0.0429 | 0.0231 | 0.0628 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | -0.0425 | 0.0231 | 0.0665 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions | -0.0569 | 0.0312 | 0.0682 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | 0.0271 | 0.0151 | 0.0721 | Wald ratio | 1 | cis | NA |
| …and 63 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
33 association rows across 21 traits (28 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| C-type lectin domain family 12 member A levels | 9e-5734 | rs588272 | 5 | GCST90247047 | no MR -> candidate analysis |
| C-type lectin domain family 12 member A levels (CLEC12A.1118 | 9e-1973 | rs2961544 | 2 | GCST90240505 | no MR -> candidate analysis |
| C-type lectin domain family 12 member A level in Chronic kid | 1e-229 | rs479499 | 1 | GCST90233113 | no MR -> candidate analysis |
| Serum levels of protein CLEC12A | 2e-149 | rs7309256 | 1 | GCST90086597 | no MR -> candidate analysis |
| CLEC12A protein levels | 9e-132 | rs111706575 | 2 | GCST90468765 | no MR -> candidate analysis |
| Serum levels of protein CLEC1B | 2e-114 | rs544605 | 2 | GCST90088666 | no MR -> candidate analysis |
| CLEC7A protein levels | 4e-87 | rs151198877 | 3 | GCST90468778 | no MR -> candidate analysis |
| Blood protein levels | 5e-70 | rs544605 | 1 | GCST006585 | no MR -> candidate analysis |
| Protein FAM171B:Extracellular domain protein levels (SomaSca | 9e-59 | rs2961544 | 1 | GCST90437795 | no MR -> candidate analysis |
| C-type lectin domain family 1 member B levels | 1e-47 | rs4763395 | 3 | GCST90247048 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 4e-25 | rs11524533 | 1 | GCST90838669 | no MR -> candidate analysis |
| C-type lectin domain family 1 member B level in Chronic kidn | 5e-18 | rs544605 | 1 | GCST90237627 | no MR -> candidate analysis |
| …and 9 more traits (see JSON) |
Top diseases by Open Targets association (of 149 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| pericarditis | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.339 | — | common-variant locus | no MR -> candidate analysis |
| non-autoimmune hemolytic anemia | 0.238 | — | common-variant locus | no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=4.4e-07, LOEUF=1.19 — LoF-tolerant |
| GWAS Catalog | 75 unique SNPs / 150 rows |
| ClinVar | 143 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 149 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CLEC12A’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 143 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 21 traits by best p-value, aggregated from 33 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q5QGZ9 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000172322/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CLEC12A — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CLEC12A — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CLEC12A%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CLEC12A — GWAS Catalog search API (live; release not exposed)