Protein Dossier — CLEC1B (C-type lectin domain family 1 member B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate |
0.122 |
0.0509 |
0.0162 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.163 |
0.0689 |
0.018 |
Wald ratio |
1 |
cis |
NA |
| Neo-openness to experience |
-0.349 |
0.158 |
0.0271 |
Wald ratio |
1 |
cis |
NA |
| Hirschsprung’s disease |
0.614 |
0.278 |
0.0272 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: arthritis (nos) |
0.121 |
0.0564 |
0.0316 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
0.0728 |
0.0361 |
0.0436 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoporosis |
-0.0984 |
0.0489 |
0.0442 |
Wald ratio |
1 |
cis |
NA |
| Type 2 diabetes |
0.0586 |
0.0295 |
0.0468 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
0.486 |
0.256 |
0.0582 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
0.0685 |
0.0365 |
0.0606 |
Wald ratio |
1 |
cis |
NA |
| Birth length |
-0.0423 |
0.0226 |
0.0617 |
Wald ratio |
1 |
cis |
NA |
| Parkinson’s disease |
-0.171 |
0.0926 |
0.0645 |
Wald ratio |
1 |
cis |
NA |
| …and 85 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4332_6_2 |
CLC1B |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
45 association rows across 39 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Blood protein levels |
1e-553 |
rs7970682 |
2 |
GCST006585 |
no MR -> candidate analysis |
| CLEC1B/SNAP29 protein level ratio |
3e-234 |
rs581949 |
1 |
GCST90314103 |
no MR -> candidate analysis |
| CLEC1B/EGF protein level ratio |
1e-180 |
rs581949 |
1 |
GCST90314089 |
no MR -> candidate analysis |
| CLEC1B/MPIG6B protein level ratio |
3e-175 |
rs581949 |
1 |
GCST90314098 |
no MR -> candidate analysis |
| CLEC1B/PPP1R2 protein level ratio |
2e-150 |
rs581949 |
1 |
GCST90314101 |
no MR -> candidate analysis |
| CLEC1B/PLXNA4 protein level ratio |
3e-150 |
rs581949 |
1 |
GCST90314100 |
no MR -> candidate analysis |
| CLEC1B/TXNDC5 protein level ratio |
8e-137 |
rs581949 |
1 |
GCST90314105 |
no MR -> candidate analysis |
| CD69/CLEC1B protein level ratio |
5e-132 |
rs76016091 |
1 |
GCST90313869 |
no MR -> candidate analysis |
| CLEC1B/MGLL protein level ratio |
3e-129 |
rs581949 |
1 |
GCST90314097 |
no MR -> candidate analysis |
| CLEC1B/F11R protein level ratio |
4e-129 |
rs581949 |
1 |
GCST90314090 |
no MR -> candidate analysis |
| Circulating CLEC1B levels |
3e-125 |
rs659928 |
2 |
GCST90859682 |
no MR -> candidate analysis |
| CLEC1B/RWDD1 protein level ratio |
3e-119 |
rs581949 |
1 |
GCST90314102 |
no MR -> candidate analysis |
| …and 27 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.4e-09, LOEUF=1.35 — LoF-tolerant |
| GWAS Catalog |
72 unique SNPs / 141 rows |
| ClinVar |
96 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 576 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CLEC1B’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 96 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 39 traits by best p-value, aggregated from 45 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9P126 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000165682/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CLEC1B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CLEC1B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CLEC1B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CLEC1B — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T01:52:49 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none