MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Clear cell ovarian cancer | -0.4 | 0.161 | 0.0131 | Wald ratio | 1 | cis | NA |
| Fracture resulting from simple fall | 0.0488 | 0.0235 | 0.0382 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.0856 | 0.0419 | 0.0408 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.015 | 0.00738 | 0.0415 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: polio or poliomyelitis | 0.483 | 0.238 | 0.0429 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.193 | 0.1 | 0.0545 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Ankle | -0.188 | 0.0985 | 0.0568 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate | 0.156 | 0.0849 | 0.0659 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | -0.0297 | 0.0168 | 0.0775 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) | 0.177 | 0.105 | 0.0915 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions | 0.196 | 0.117 | 0.0935 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: arthritis (nos) | -0.233 | 0.141 | 0.0974 | Wald ratio | 1 | cis | NA |
| …and 48 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
101 association rows across 63 traits (83 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Ectonucleotide pyrophosphatase/phosphodiesterase family memb | 1e-717 | rs4714902 | 1 | GCST90247463 | no MR -> candidate analysis |
| Ectonucleotide pyrophosphatase/phosphodiesterase family memb | 8e-278 | rs144538541 | 1 | GCST90241026 | no MR -> candidate analysis |
| Chloride intracellular channel protein 5 levels | 1e-189 | rs35822882 | 2 | GCST90247063 | no MR -> candidate analysis |
| Blood protein levels | 2e-182 | rs62400860 | 2 | GCST006585 | no MR -> candidate analysis |
| ENPP5 protein levels | 7e-105 | rs116286373 | 21 | GCST90469116 | no MR -> candidate analysis |
| Serum levels of protein CLIC5 | 3e-95 | rs35822882 | 1 | GCST90087010 | no MR -> candidate analysis |
| CLIC5 protein levels | 3e-69 | rs9381421 | 2 | GCST90468780 | no MR -> candidate analysis |
| Height | 3e-67 | rs1388244 | 9 | GCST90245848 | no MR -> candidate analysis |
| Chloride intracellular channel protein 5 levels (CLIC5.12475 | 7e-27 | rs35822882 | 1 | GCST90240686 | no MR -> candidate analysis |
| TGF-beta receptor type-1 protein levels (SomaScan ID:6556-5) | 1e-24 | rs144538541 | 1 | GCST90441524 | no MR -> candidate analysis |
| GLIPR1 protein levels | 4e-23 | rs549005520 | 2 | GCST90469357 | no MR -> candidate analysis |
| HPSE protein levels | 2e-22 | rs7766019 | 1 | GCST90469473 | no MR -> candidate analysis |
| …and 51 more traits (see JSON) |
Top diseases by Open Targets association (of 1575 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hearing loss, autosomal recessive | 0.732 | — | established (curated) | no MR -> candidate analysis |
| deafness | 0.764 | — | established (curated) | no MR -> candidate analysis |
| open-angle glaucoma | 0.708 | — | common-variant locus | no MR -> candidate analysis |
| hair color | 0.685 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.503 | — | common-variant locus | no MR -> candidate analysis |
| external ear disorder | 0.5 | — | common-variant locus | no MR -> candidate analysis |
| Proteinuria | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| chronic venous hypertension | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| severe acute respiratory syndrome | 0.465 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.465 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhage | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| gastric ulcer | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| breast disorder | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.441 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.1e-06, LOEUF=1.18 — LoF-tolerant |
| GWAS Catalog | 124 unique SNPs / 255 rows |
| ClinVar | 225 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1575 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CLIC5’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 225 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 63 traits by best p-value, aggregated from 101 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NZA1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000112782/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CLIC5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CLIC5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CLIC5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CLIC5 — GWAS Catalog search API (live; release not exposed)