MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Heel bone mineral density (BMD) T-score automated | -0.0489 | 0.0127 | 1.14e-04 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.0333 | 0.01 | 8.63e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: joint disorder | 0.331 | 0.104 | 0.00142 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.0234 | 0.00763 | 0.00217 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | 0.583 | 0.194 | 0.0027 | Wald ratio | 1 | cis | NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0894 | 0.0301 | 0.00295 | Wald ratio | 1 | cis | NA |
| Mean platelet volume | 0.0116 | 0.00401 | 0.00373 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0449 | 0.0159 | 0.00483 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0698 | 0.0253 | 0.00575 | Wald ratio | 1 | cis | NA |
| Glioma | -0.482 | 0.179 | 0.00709 | Wald ratio | 1 | cis | NA |
| Pulse rate | -0.0448 | 0.0172 | 0.00927 | Wald ratio | 1 | cis | NA |
| Haemoglobin concentration | 0.0626 | 0.0241 | 0.00932 | Wald ratio | 1 | cis | NA |
| …and 109 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
101 association rows across 58 traits (78 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating CLMP levels | 3e-805 | rs2302605 | 5 | GCST90860328 | no MR -> candidate analysis |
| CLMP/PIK3IP1 protein level ratio | 3e-556 | rs7113140 | 1 | GCST90314134 | no MR -> candidate analysis |
| CLMP protein levels | 2e-148 | rs11218995 | 10 | GCST90468783 | no MR -> candidate analysis |
| CXADR-like membrane protein levels | 5e-68 | rs2155572 | 2 | GCST90247200 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 1e-64 | rs190733142 | 1 | GCST90838671 | no MR -> candidate analysis |
| Mean corpuscular hemoglobin concentration | 5e-43 | rs113954756 | 8 | GCST90002332 | no MR -> candidate analysis |
| mean corpuscular hemoglobin concentration (MCHC, mean, inv-n | 3e-42 | rs11218953 | 1 | GCST90479670 | no MR -> candidate analysis |
| heart rate (HR, mean, inv-normal transformed) | 9e-42 | rs7113140 | 2 | GCST90476338 | no MR -> candidate analysis |
| Red cell distribution width | 3e-35 | rs7933208 | 5 | GCST90002372 | no MR -> candidate analysis |
| Serum levels of protein CLMP | 4e-35 | rs7941947 | 1 | GCST90086270 | no MR -> candidate analysis |
| HSPA1A/WWP2 protein level ratio | 1e-32 | rs2276348 | 1 | GCST90315086 | no MR -> candidate analysis |
| FIS1/HSPA1A protein level ratio | 1e-31 | rs2276348 | 1 | GCST90314825 | no MR -> candidate analysis |
| …and 46 more traits (see JSON) |
Top diseases by Open Targets association (of 850 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| congenital short bowel syndrome | 0.603 | — | established (curated) | no MR -> candidate analysis |
| congenital short bowel syndrome, autosomal recessive | 0.824 | — | established (curated) | no MR -> candidate analysis |
| intestinal pseudo-obstruction | 0.717 | — | established (curated) | no MR -> candidate analysis |
| disorder of ear | 0.507 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.47 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhoid | 0.443 | — | common-variant locus | no MR -> candidate analysis |
| central nervous system cancer | 0.429 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.316 | — | established (curated) | no MR -> candidate analysis |
| response to stimulus | 0.284 | — | common-variant locus | no MR -> candidate analysis |
| hyperpituitarism | 0.276 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.276 | — | common-variant locus | no MR -> candidate analysis |
| cardiomyopathy | 0.272 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.236 | — | common-variant locus | no MR -> candidate analysis |
| cancer | 0.236 | — | common-variant locus | MR: beta=0.331, p=0.00142 (cis) |
| diabetes mellitus | 0.236 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.3e-05, LOEUF=0.824 — LoF-tolerant |
| GWAS Catalog | 95 unique SNPs / 196 rows |
| ClinVar | 128 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 850 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CLMP’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 128 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 58 traits by best p-value, aggregated from 101 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9H6B4 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000166250/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CLMP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CLMP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CLMP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CLMP — GWAS Catalog search API (live; release not exposed)