MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Bipolar disorder | -0.521 | 0.126 | 3.53e-05 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: depression | 0.132 | 0.0493 | 0.00756 | Wald ratio | 1 | cis | NA |
| Years of schooling | 0.046 | 0.0172 | 0.00766 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: migraine | 0.162 | 0.0672 | 0.0159 | Wald ratio | 1 | cis | NA |
| Major depressive disorder | -0.261 | 0.117 | 0.0261 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.164 | 0.0752 | 0.029 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | 0.427 | 0.199 | 0.0317 | Wald ratio | 1 | cis | NA |
| Height | -0.0345 | 0.0161 | 0.0321 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.279 | 0.135 | 0.0389 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | -0.135 | 0.0667 | 0.0433 | Wald ratio | 1 | cis | NA |
| Putamen volume | -64.8 | 32.9 | 0.0486 | Wald ratio | 1 | cis | NA |
| Multiple sclerosis | -0.178 | 0.0909 | 0.0498 | Wald ratio | 1 | cis | NA |
| …and 92 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
14 association rows across 12 traits (11 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 8e-40 | rs2051950 | 1 | GCST90245848 | MR: beta=-0.0345, p=0.0321 (cis) |
| ADAM22 protein levels | 2e-28 | rs79797038 | 1 | GCST90468218 | no MR -> candidate analysis |
| Serum levels of protein CROT | 5e-24 | rs7776867 | 1 | GCST90087661 | no MR -> candidate analysis |
| Chronic elevation of alanine aminotransferase (cALT) levels | 4e-21 | rs115038698 | 2 | GCST90129601 | no MR -> candidate analysis |
| Aspartate aminotransferase (AST, mean, inv-norm transformed) | 2e-18 | rs147423000 | 1 | GCST90479510 | no MR -> candidate analysis |
| Aspartate aminotransferase (AST, minimum, inv-norm transform | 4e-14 | rs144656711 | 2 | GCST90479511 | no MR -> candidate analysis |
| Blood protein levels | 2e-13 | rs77463367 | 1 | GCST006585 | no MR -> candidate analysis |
| Peroxisomal carnitine O-octanoyltransferase levels | 1e-11 | rs117788595 | 1 | GCST90422349 | no MR -> candidate analysis |
| Aspartate aminotransferase levels | 1e-10 | rs28860289 | 1 | GCST90244010 | no MR -> candidate analysis |
| Lung cancer | 1e-6 | rs148791337 | 1 | GCST004748 | no MR -> candidate analysis |
| interferon-related traits | 4e-6 | rs77270176 | 1 | GCST012156 | no MR -> candidate analysis |
| TRAIL levels | 7e-6 | rs181732910 | 1 | GCST004424 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 92 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the liver | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| hidradenitis | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| Intrahepatic cholestasis of pregnancy | 0.395 | — | common-variant locus | no MR -> candidate analysis |
| cholestasis, intrahepatic, of pregnancy 3 | 0.227 | — | common-variant locus | no MR -> candidate analysis |
| gastrointestinal disease | 0.166 | — | common-variant locus | no MR -> candidate analysis |
| cholelithiasis | 0.132 | — | common-variant locus | MR: beta=0.0883, p=0.313 (cis) |
| Cholecystitis | 0.121 | — | common-variant locus | no MR -> candidate analysis |
| lagophthalmos | 0.043 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.033 | — | common-variant locus | no MR -> candidate analysis |
Of the 11 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Peroxisomal carnitine O-octanoyltransferase) |
| gnomAD constraint | pLI=2.9e-27, LOEUF=1.13 — LoF-tolerant |
| GWAS Catalog | 71 unique SNPs / 142 rows |
| ClinVar | 137 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 92 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CROT’ and resolved to ‘Peroxisomal carnitine O-octanoyltransferase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 137 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 12 of 12 traits by best p-value, aggregated from 14 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9UKG9 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000005469/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2206/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CROT — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CROT — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CROT%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CROT — GWAS Catalog search API (live; release not exposed)