Protein Dossier — CRP (C-reactive protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Heel bone mineral density (BMD) T-score automated |
-0.0514 |
0.0143 |
3.33e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0514 |
0.0143 |
3.33e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0514 |
0.0143 |
3.33e-04 |
Inverse variance weighted |
3 |
cis |
NA |
| Schizophrenia |
-0.132 |
0.0414 |
0.00143 |
Inverse variance weighted |
3 |
trans |
NA |
| Schizophrenia |
-0.132 |
0.0414 |
0.00143 |
Inverse variance weighted |
3 |
trans |
NA |
| Schizophrenia |
-0.132 |
0.0414 |
0.00143 |
Inverse variance weighted |
3 |
cis |
NA |
| Age at menarche |
0.0726 |
0.0232 |
0.00179 |
Inverse variance weighted |
3 |
trans |
NA |
| Age at menarche |
0.0726 |
0.0232 |
0.00179 |
Inverse variance weighted |
3 |
trans |
NA |
| Age at menarche |
0.0726 |
0.0232 |
0.00179 |
Inverse variance weighted |
3 |
cis |
NA |
| Happiness |
0.0285 |
0.0116 |
0.0144 |
Inverse variance weighted |
3 |
trans |
NA |
| Happiness |
0.0285 |
0.0116 |
0.0144 |
Inverse variance weighted |
3 |
trans |
NA |
| Happiness |
0.0285 |
0.0116 |
0.0144 |
Inverse variance weighted |
3 |
cis |
NA |
| …and 318 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4337_49_2 |
CRP |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
153 association rows across 40 traits (143 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| C-reactive protein levels |
8e-1349 |
rs7551731 |
51 |
GCST009777 |
no MR -> candidate analysis |
| C-reactive protein |
6e-1003 |
rs2211320 |
10 |
GCST90018950 |
no MR -> candidate analysis |
| High-sensitivity C-reactive protein levels |
1e-304 |
rs3093068 |
6 |
GCST90503209 |
no MR -> candidate analysis |
| C-reactive protein levels (MTAG) |
4e-210 |
rs3116654 |
9 |
GCST90179146 |
no MR -> candidate analysis |
| Low-density lipoprotein levels (MTAG) |
2e-205 |
rs1205 |
6 |
GCST90179148 |
no MR -> candidate analysis |
| C-reactive protein levels (UKB data field 30710) |
4e-165 |
rs55910253 |
17 |
GCST90468064 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
2e-78 |
rs4131568 |
1 |
GCST90838667 |
no MR -> candidate analysis |
| Multi-trait sum score |
5e-40 |
rs12037186 |
10 |
GCST90270117 |
no MR -> candidate analysis |
| FCRL6 protein levels |
7e-36 |
rs183345522 |
7 |
GCST90469209 |
no MR -> candidate analysis |
| SLAMF8 protein levels |
1e-30 |
rs185749924 |
2 |
GCST90470652 |
no MR -> candidate analysis |
| High-density lipoprotein levels (MTAG) |
8e-27 |
rs4546916 |
2 |
GCST90179147 |
no MR -> candidate analysis |
| High-sensitivity C-reactive protein levels in HIV infection |
2e-25 |
rs6667499 |
2 |
GCST012140 |
no MR -> candidate analysis |
| …and 28 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 3009 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| pneumonia |
0.771 |
— |
common-variant locus |
no MR -> candidate analysis |
| bacterial infectious disease |
0.765 |
— |
common-variant locus |
no MR -> candidate analysis |
| influenza |
0.669 |
— |
common-variant locus |
no MR -> candidate analysis |
| bacterial pneumonia |
0.619 |
— |
common-variant locus |
no MR -> candidate analysis |
| inflammatory response |
0.549 |
— |
common-variant locus |
no MR -> candidate analysis |
| nephritis |
0.549 |
— |
common-variant locus |
no MR -> candidate analysis |
| Prosthesis-Related Infections |
0.536 |
— |
common-variant locus |
no MR -> candidate analysis |
| interstitial nephritis |
0.501 |
— |
common-variant locus |
no MR -> candidate analysis |
| renal tubule disorder |
0.501 |
— |
common-variant locus |
no MR -> candidate analysis |
| squamous cell carcinoma |
0.22 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental abruption |
0.216 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 11 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Cysteine and glycine-rich protein 1) |
| gnomAD constraint |
pLI=0.00076, LOEUF=3.99 — LoF-tolerant |
| GWAS Catalog |
133 unique SNPs / 342 rows |
| ClinVar |
42 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
4 clinical annotations across 3 drugs |
phenome — Top 30 of 3009 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CRP’ and resolved to ‘Cysteine and glycine-rich protein 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 42 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 40 traits by best p-value, aggregated from 153 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P02741 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000132693/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295728/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CRP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CRP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CRP%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CRP — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CRP — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:04:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none