MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Amyotrophic lateral sclerosis | -0.169 | 0.057 | 0.00301 | Wald ratio | 1 | cis | NA |
| 2hr glucose | 0.171 | 0.0602 | 0.00448 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | 0.118 | 0.0487 | 0.0151 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | 0.183 | 0.0764 | 0.0165 | Wald ratio | 1 | cis | NA |
| Alzheimer’s disease | -0.117 | 0.0494 | 0.0183 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | 0.167 | 0.0723 | 0.021 | Wald ratio | 1 | cis | NA |
| Schizophrenia | -0.0785 | 0.0342 | 0.0217 | Wald ratio | 1 | cis | NA |
| Hip osteoarthritis | 0.196 | 0.086 | 0.0227 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse | 0.19 | 0.0866 | 0.0284 | Wald ratio | 1 | cis | NA |
| Fasting proinsulin | 0.0475 | 0.0228 | 0.0372 | Wald ratio | 1 | cis | NA |
| Endometrioid ovarian cancer | 0.191 | 0.092 | 0.0374 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.0443 | 0.0222 | 0.0455 | Wald ratio | 1 | cis | NA |
| …and 91 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
102 association rows across 38 traits (92 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Cytokine receptor common subunit beta levels | 6e-850 | rs5756415 | 1 | GCST90247148 | no MR -> candidate analysis |
| Serum levels of protein CSF2RB | 2e-204 | rs1534881 | 1 | GCST90086315 | no MR -> candidate analysis |
| CSF2RB protein levels | 2e-120 | rs7292430 | 27 | GCST90468883 | no MR -> candidate analysis |
| Blood protein levels | 1e-100 | rs5756414 | 1 | GCST006585 | no MR -> candidate analysis |
| PVALB protein levels | 1e-69 | rs770332956 | 10 | GCST90470393 | no MR -> candidate analysis |
| Atopic dermatitis | 5e-50 | rs4821569 | 7 | GCST90244787 | no MR -> candidate analysis |
| Eosinophil count | 1e-45 | rs117582568 | 10 | GCST90002299 | no MR -> candidate analysis |
| Cytokine receptor common subunit beta level in Chronic kidne | 2e-41 | rs5756414 | 1 | GCST90232896 | no MR -> candidate analysis |
| Basophil count | 2e-38 | rs117582568 | 3 | GCST90002293 | no MR -> candidate analysis |
| Cytokine receptor common subunit beta levels (CSF2RB.10512.1 | 3e-38 | rs1534881 | 1 | GCST90240859 | no MR -> candidate analysis |
| Oncostatin-M-specific receptor subunit beta protein levels ( | 5e-27 | rs5756415 | 1 | GCST90439860 | no MR -> candidate analysis |
| Cerebrospinal fluid protein CSF2RB levels | 7e-25 | rs2239749 | 1 | GCST90943238 | no MR -> candidate analysis |
| …and 26 more traits (see JSON) |
Top diseases by Open Targets association (of 626 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Congenital pulmonary alveolar proteinosis | 0.721 | — | established (curated) | no MR -> candidate analysis |
| Crohn disease | 0.581 | — | common-variant locus | no MR -> candidate analysis |
| atopic eczema | 0.676 | — | common-variant locus | no MR -> candidate analysis |
| dermatitis | 0.647 | — | common-variant locus | no MR -> candidate analysis |
| hereditary pulmonary alveolar proteinosis | 0.608 | — | established (curated) | no MR -> candidate analysis |
| psoriasis | 0.543 | — | common-variant locus | MR: beta=-0.0892, p=0.261 (cis) |
| Eczematoid dermatitis | 0.522 | — | common-variant locus | no MR -> candidate analysis |
| inflammatory bowel disease | 0.513 | — | common-variant locus | no MR -> candidate analysis |
| psoriasis vulgaris | 0.473 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Innate repair receptor) |
| gnomAD constraint | pLI=1, LOEUF=0.468 — LoF-INTOLERANT |
| GWAS Catalog | 119 unique SNPs / 290 rows |
| ClinVar | 907 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 626 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CSF2RB’ and resolved to ‘Innate repair receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 907 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 38 traits by best p-value, aggregated from 102 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P32927 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000100368/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4804252/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CSF2RB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CSF2RB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CSF2RB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CSF2RB — GWAS Catalog search API (live; release not exposed)