MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: K40 Inguinal hernia | 0.158 | 0.0435 | 2.85e-04 | Wald ratio | 1 | cis | NA |
| Haemoglobin concentration | -0.0943 | 0.0303 | 0.00186 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0222 | 0.00719 | 0.00202 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.019 | 0.00682 | 0.00539 | Wald ratio | 1 | cis | NA |
| Birth length | -0.0867 | 0.0331 | 0.00891 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: uterine fibroids | 0.151 | 0.0579 | 0.00915 | Wald ratio | 1 | cis | NA |
| Packed cell volume | -0.217 | 0.0836 | 0.00941 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | -0.13 | 0.0532 | 0.0143 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0518 | 0.0212 | 0.0147 | Wald ratio | 1 | cis | NA |
| Height | 0.0235 | 0.00992 | 0.0177 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.113 | 0.048 | 0.0184 | Wald ratio | 1 | cis | NA |
| Transferrin | -0.0799 | 0.0351 | 0.023 | Wald ratio | 1 | cis | NA |
| …and 84 more outcomes (see JSON) |
| Dataset | Trait | Author | Year |
|---|---|---|---|
prot-c-2975_19_2 |
CTGF | Suhre K | 2019 |
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 3866 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| kyphomelic dysplasia | 0.684 | — | established (curated) | no MR -> candidate analysis |
| spondyloepimetaphyseal dysplasia, Li-Shao-Li type | 0.547 | — | established (curated) | no MR -> candidate analysis |
| vertebral column disorder | 0.463 | — | common-variant locus | no MR -> candidate analysis |
| cardiomyopathy | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| enteritis | 0.401 | — | common-variant locus | no MR -> candidate analysis |
| aortic stenosis | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| secondary malignant neoplasm | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| Hyperhidrosis | 0.353 | — | common-variant locus | no MR -> candidate analysis |
| non-autoimmune hemolytic anemia | 0.334 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary embolism | 0.25 | — | common-variant locus | MR: beta=0.102, p=0.226 (cis) |
Of the 10 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (CCN family member 2) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 3866 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CTGF’ and resolved to ‘CCN family member 2’ — confirm this is the intended target.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/P29279 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000118523/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3712901/ — ChEMBL_37 (released 2026-05-01)