Protein Dossier — CXCL10 (C-X-C motif chemokine 10)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Alzheimer’s disease |
-0.345 |
0.117 |
0.00306 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.335 |
0.124 |
0.0068 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.146 |
0.0568 |
0.01 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.29 |
0.127 |
0.023 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
-0.172 |
0.0784 |
0.0281 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.496 |
0.23 |
0.0309 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0597 |
0.029 |
0.0399 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.165 |
0.0812 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
-0.188 |
0.0979 |
0.0552 |
Wald ratio |
1 |
cis |
NA |
| Happiness |
-0.0423 |
0.0224 |
0.0587 |
Wald ratio |
1 |
cis |
NA |
| Autism |
0.403 |
0.214 |
0.0594 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.0262 |
0.0141 |
0.0634 |
Wald ratio |
1 |
cis |
NA |
| …and 91 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4141_79_1 |
IP-10 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
7 association rows across 5 traits (7 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| C-X-C motif chemokine 10 levels |
6e-271 |
rs11548618 |
3 |
GCST90274780 |
no MR -> candidate analysis |
| C-X-C motif chemokine 10 levels (CXCL10.4141.79.1) |
2e-49 |
rs11548618 |
1 |
GCST90240520 |
no MR -> candidate analysis |
| CXCL10 levels |
2e-37 |
rs11548618 |
1 |
GCST90274886 |
no MR -> candidate analysis |
| CXCL10 protein levels |
2e-17 |
rs11548618 |
1 |
GCST90277748 |
no MR -> candidate analysis |
| Neonatal cytokine/chemokine levels (fetal genetic effect) |
2e-14 |
rs3921 |
1 |
GCST006622 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (C-X-C motif chemokine 10) |
| gnomAD constraint |
pLI=0.063, LOEUF=1.09 — LoF-tolerant |
| GWAS Catalog |
105 unique SNPs / 228 rows |
| ClinVar |
53 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 2 drugs |
phenome — Top 30 of 1518 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘CXCL10’ and resolved to ‘C-X-C motif chemokine 10’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 53 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 5 of 5 traits by best p-value, aggregated from 7 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P02778 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000169245/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3712964/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/CXCL10 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CXCL10 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CXCL10%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=CXCL10 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/CXCL10 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:13:30 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none