Protein Dossier — CXCL11 (C-X-C motif chemokine 11)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Alzheimer’s disease |
0.22 |
0.0687 |
0.00137 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.2 |
0.0804 |
0.0129 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.0724 |
0.0301 |
0.0161 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.0983 |
0.0448 |
0.0281 |
Wald ratio |
1 |
cis |
NA |
| Happiness |
0.0274 |
0.0128 |
0.0324 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0362 |
0.017 |
0.0333 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
-0.153 |
0.0725 |
0.0353 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.0168 |
0.00807 |
0.0371 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: depression |
0.0811 |
0.0394 |
0.0395 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.306 |
0.154 |
0.0464 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
-50.6 |
26.3 |
0.0546 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
0.107 |
0.0559 |
0.0552 |
Wald ratio |
1 |
cis |
NA |
| …and 90 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3038_9_2 |
I-TAC |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
6 association rows across 4 traits (5 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| CXCL11 protein levels |
3e-67 |
rs190426994 |
2 |
GCST90468924 |
no MR -> candidate analysis |
| C-X-C motif chemokine 11 levels |
5e-32 |
rs115354596 |
2 |
GCST90247202 |
no MR -> candidate analysis |
| C-X-C motif chemokine 11 level in Chronic kidney disease wit |
2e-22 |
rs12509255 |
1 |
GCST90237209 |
no MR -> candidate analysis |
| N-acylethanolamine-hydrolyzing acid amidase levels |
1e-7 |
rs56961181 |
1 |
GCST90248592 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.01, LOEUF=1.36 — LoF-tolerant |
| GWAS Catalog |
101 unique SNPs / 211 rows |
| ClinVar |
51 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 655 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CXCL11’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 51 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 6 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O14625 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000169248/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CXCL11 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CXCL11 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CXCL11%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CXCL11 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:13:44 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none