Protein Dossier — CXCL16 (C-X-C motif chemokine 16)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Crohn’s disease |
-0.475 |
0.0977 |
1.14e-06 |
Wald ratio |
1 |
trans |
NA |
| Inflammatory bowel disease |
-0.387 |
0.0809 |
1.71e-06 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: depression |
0.00687 |
0.00217 |
0.00158 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: depression |
0.00687 |
0.00217 |
0.00158 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: depression |
0.00687 |
0.00217 |
0.00158 |
Inverse variance weighted |
3 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0412 |
0.0136 |
0.00236 |
Inverse variance weighted |
3 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0412 |
0.0136 |
0.00236 |
Inverse variance weighted |
3 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0412 |
0.0136 |
0.00236 |
Inverse variance weighted |
3 |
cis |
NA |
| Ulcerative colitis |
-0.303 |
0.102 |
0.00303 |
Wald ratio |
1 |
trans |
NA |
| Age at menopause |
0.19 |
0.0684 |
0.00553 |
Inverse variance weighted |
3 |
trans |
NA |
| Age at menopause |
0.19 |
0.0684 |
0.00553 |
Inverse variance weighted |
3 |
trans |
NA |
| Age at menopause |
0.19 |
0.0684 |
0.00553 |
Inverse variance weighted |
3 |
cis |
NA |
| …and 271 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2436_49_4 |
CXCL16, soluble |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
10 association rows across 4 traits (10 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CXCL16 levels |
2e-216 |
rs2304970 |
2 |
GCST90859949 |
no MR -> candidate analysis |
| CXCL16 protein levels |
4e-199 |
rs60894000 |
2 |
GCST90468928 |
no MR -> candidate analysis |
| VMO1 protein levels |
2e-59 |
rs186708492 |
2 |
GCST90471042 |
no MR -> candidate analysis |
| C-X-C motif chemokine 16 levels |
3e-42 |
rs1876444 |
4 |
GCST90247204 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 543 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| arthropathy |
0.211 |
— |
common-variant locus |
no MR -> candidate analysis |
| nasal cavity polyp |
0.157 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.7e-05, LOEUF=1.12 — LoF-tolerant |
| GWAS Catalog |
104 unique SNPs / 218 rows |
| ClinVar |
78 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 543 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CXCL16’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 78 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 10 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9H2A7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000161921/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CXCL16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CXCL16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CXCL16%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CXCL16 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:13:59 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none