Protein Dossier — CXCL1 (Growth-regulated alpha protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
0.0739 |
0.0268 |
0.00591 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.009 |
0.00329 |
0.0062 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.00807 |
0.00312 |
0.00962 |
Wald ratio |
1 |
cis |
NA |
| Large vessel disease |
0.121 |
0.0532 |
0.0226 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: ankylosing spondylitis |
0.133 |
0.0632 |
0.0353 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.105 |
0.0507 |
0.038 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
-0.0107 |
0.00536 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: arthritis (nos) |
-0.0959 |
0.0482 |
0.0468 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
-0.0798 |
0.043 |
0.0636 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms |
0.0535 |
0.0293 |
0.0682 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Glaucoma |
0.0533 |
0.0301 |
0.0768 |
Wald ratio |
1 |
cis |
NA |
| Years of schooling |
0.00938 |
0.00536 |
0.0801 |
Wald ratio |
1 |
cis |
NA |
| …and 83 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2985_35_1 |
Gro-a |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
95 association rows across 54 traits (91 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CXCL1 levels (id: OID00404_OID20762) |
5e-1754 |
rs2115691 |
2 |
GCST90859766 |
no MR -> candidate analysis |
| Circulating CXCL1 levels (id: OID00786_OID20762) |
6e-1709 |
rs2115691 |
2 |
GCST90860118 |
no MR -> candidate analysis |
| Circulating CXCL1 levels (id: OID00496_OID20762) |
1e-1652 |
rs2115691 |
2 |
GCST90859853 |
no MR -> candidate analysis |
| Growth-regulated alpha protein levels |
2e-1526 |
rs3097411 |
9 |
GCST90247816 |
no MR -> candidate analysis |
| CXCL3/CXCL5 protein level ratio |
6e-1230 |
rs352024 |
1 |
GCST90314344 |
no MR -> candidate analysis |
| CXCL1/CXCL5 protein level ratio |
2e-1218 |
rs352024 |
1 |
GCST90314343 |
no MR -> candidate analysis |
| CCL5/CXCL5 protein level ratio |
1e-1011 |
rs352024 |
1 |
GCST90313701 |
no MR -> candidate analysis |
| CXCL5/PPIB protein level ratio |
1e-899 |
rs352024 |
1 |
GCST90314352 |
no MR -> candidate analysis |
| CXCL5/SERPINE1 protein level ratio |
3e-839 |
rs352024 |
1 |
GCST90314354 |
no MR -> candidate analysis |
| CXCL5/SPARC protein level ratio |
4e-757 |
rs352024 |
1 |
GCST90314355 |
no MR -> candidate analysis |
| CXCL5/PLXNA4 protein level ratio |
1e-717 |
rs352024 |
1 |
GCST90314351 |
no MR -> candidate analysis |
| CXCL5/SDC4 protein level ratio |
1e-678 |
rs352024 |
1 |
GCST90314353 |
no MR -> candidate analysis |
| …and 42 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
No genetically-associated diseases retrieved from Open Targets.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0024, LOEUF=1.34 — LoF-tolerant |
| GWAS Catalog |
104 unique SNPs / 222 rows |
| ClinVar |
54 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1109 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CXCL1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 54 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 54 traits by best p-value, aggregated from 95 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P09341 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163739/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CXCL1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CXCL1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CXCL1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CXCL1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:13:13 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none