Protein Dossier — CXCL6 (C-X-C motif chemokine 6)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
0.00644 |
0.00249 |
0.00954 |
Wald ratio |
1 |
cis |
NA |
| Forearm bone mineral density |
-0.0486 |
0.019 |
0.0107 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.0303 |
0.0122 |
0.0129 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoarthritis |
-0.0236 |
0.00964 |
0.0143 |
Wald ratio |
1 |
cis |
NA |
| Body fat |
-0.0472 |
0.0203 |
0.0199 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
-0.0469 |
0.0208 |
0.0238 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.00459 |
0.0022 |
0.0369 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K35 Acute appendicitis |
-0.0908 |
0.0443 |
0.0406 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.00481 |
0.00244 |
0.0482 |
Wald ratio |
1 |
cis |
NA |
| Cough on most days |
0.0276 |
0.0141 |
0.0498 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
0.0661 |
0.0346 |
0.056 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast |
0.0391 |
0.0212 |
0.0645 |
Wald ratio |
1 |
cis |
NA |
| …and 85 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3495_15_2 |
GCP-2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
220 association rows across 112 traits (214 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CXCL6 levels |
2e-2252 |
rs16850073 |
4 |
GCST90859888 |
no MR -> candidate analysis |
| CXCL6/LAT protein level ratio |
4e-1490 |
rs9999262 |
1 |
GCST90314358 |
no MR -> candidate analysis |
| CXCL6/DFFA protein level ratio |
4e-1458 |
rs9999262 |
1 |
GCST90314357 |
no MR -> candidate analysis |
| CCL13/CXCL6 protein level ratio |
1e-1301 |
rs9999262 |
1 |
GCST90313677 |
no MR -> candidate analysis |
| C-X-C motif chemokine 6 levels |
7e-1224 |
rs16850073 |
12 |
GCST90247207 |
no MR -> candidate analysis |
| CXCL6/CXCL8 protein level ratio |
5e-1176 |
rs9999262 |
1 |
GCST90314356 |
no MR -> candidate analysis |
| Platelet factor 4 variant levels |
4e-1101 |
rs2367288 |
1 |
GCST90248967 |
no MR -> candidate analysis |
| Serum levels of protein TNFAIP8 |
1e-300 |
rs2367288 |
1 |
GCST90087071 |
no MR -> candidate analysis |
| Blood protein levels |
2e-250 |
rs872914 |
52 |
GCST006585 |
no MR -> candidate analysis |
| Serum levels of protein ID2 |
1e-206 |
rs2367288 |
1 |
GCST90090689 |
no MR -> candidate analysis |
| Serum levels of protein RAB39B |
8e-189 |
rs2367288 |
1 |
GCST90086961 |
no MR -> candidate analysis |
| Serum levels of protein SLC3A2 |
2e-169 |
rs61360774 |
1 |
GCST90089635 |
no MR -> candidate analysis |
| …and 100 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 415 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hypertrophic cardiomyopathy |
0.337 |
— |
common-variant locus |
MR: beta=0.195, p=0.246 (cis) |
| atrial fibrillation |
0.06 |
— |
common-variant locus |
MR: beta=0.0259, p=0.319 (cis) |
Of the 2 rows above, 0 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3.4e-09, LOEUF=2.54 — LoF-tolerant |
| GWAS Catalog |
113 unique SNPs / 232 rows |
| ClinVar |
50 records; 7 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 415 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘CXCL6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 50 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 112 traits by best p-value, aggregated from 220 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P80162 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000124875/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/CXCL6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/CXCL6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=CXCL6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/CXCL6 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:14:12 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none