Protein Dossier — DAPK2 (Death-associated protein kinase 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: I30 Acute pericarditis |
0.592 |
0.213 |
0.0055 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd |
0.235 |
0.0874 |
0.00714 |
Wald ratio |
1 |
cis |
NA |
| Creatinine (enzymatic) in urine |
0.016 |
0.00613 |
0.00922 |
Wald ratio |
1 |
cis |
NA |
| Packed cell volume |
-0.124 |
0.0486 |
0.0105 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.131 |
0.053 |
0.0132 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.0994 |
0.0404 |
0.0139 |
Wald ratio |
1 |
cis |
NA |
| LDL cholesterol |
0.0337 |
0.0138 |
0.0146 |
Wald ratio |
1 |
cis |
NA |
| Chronic kidney disease |
-0.0955 |
0.0398 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| HDL cholesterol |
0.0303 |
0.0127 |
0.0175 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.165 |
0.0711 |
0.02 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.184 |
0.0805 |
0.0223 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
-0.0736 |
0.0333 |
0.0271 |
Wald ratio |
1 |
cis |
NA |
| …and 98 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4355_13_1 |
DAPK2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
43 association rows across 32 traits (29 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Death-associated protein kinase 2 levels |
2e-150 |
rs4436737 |
3 |
GCST90247234 |
no MR -> candidate analysis |
| Death-associated protein kinase 1 levels |
2e-117 |
rs55986634 |
1 |
GCST90247233 |
no MR -> candidate analysis |
| DAPK2 protein levels |
5e-109 |
rs2414840 |
7 |
GCST90468945 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
3e-18 |
rs187236774 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| Height |
3e-15 |
rs17788704 |
3 |
GCST90245848 |
MR: beta=0.00557, p=0.469 (cis) |
| HDL cholesterol levels |
4e-15 |
rs34675318 |
1 |
GCST010242 |
no MR -> candidate analysis |
| Thyroid stimulating hormone levels |
2e-14 |
rs1542244 |
1 |
GCST90572789 |
no MR -> candidate analysis |
| Standing height (UKB data field 50) |
3e-12 |
rs145586222 |
1 |
GCST90468178 |
no MR -> candidate analysis |
| Mean corpuscular volume |
7e-12 |
rs72755040 |
1 |
GCST90056174 |
no MR -> candidate analysis |
| Height (baseline) |
3e-11 |
rs17775820 |
1 |
GCST90565843 |
no MR -> candidate analysis |
| Platelet distribution width |
6e-10 |
rs141207816 |
1 |
GCST004616 |
no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Any Bre |
3e-9 |
rs72755006 |
1 |
GCST90569450 |
no MR -> candidate analysis |
| …and 20 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 124 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.536 |
— |
common-variant locus |
no MR -> candidate analysis |
| eye disorder |
0.394 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypothyroidism |
0.106 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental abruption |
0.049 |
— |
common-variant locus |
no MR -> candidate analysis |
| gastric ulcer |
0.045 |
— |
common-variant locus |
no MR -> candidate analysis |
| hemorrhage |
0.045 |
— |
common-variant locus |
no MR -> candidate analysis |
| IgA glomerulonephritis |
0.04 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Death-associated protein kinase 2) |
| gnomAD constraint |
pLI=3.8e-10, LOEUF=1.05 — LoF-tolerant |
| GWAS Catalog |
75 unique SNPs / 146 rows |
| ClinVar |
99 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 124 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DAPK2’ and resolved to ‘Death-associated protein kinase 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 99 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 32 traits by best p-value, aggregated from 43 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UIK4 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000035664/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3123/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DAPK2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DAPK2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DAPK2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DAPK2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:14:51 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none