MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.318 | 0.0893 | 3.67e-04 | Wald ratio | 1 | cis | NA |
| Age at menarche | -0.0694 | 0.0216 | 0.0013 | Wald ratio | 1 | cis | NA |
| Height | -0.0323 | 0.0111 | 0.00375 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.263 | 0.0925 | 0.00453 | Wald ratio | 1 | cis | NA |
| Weight | -0.0194 | 0.00773 | 0.012 | Wald ratio | 1 | cis | NA |
| Large vessel disease | -0.312 | 0.124 | 0.0122 | Wald ratio | 1 | cis | NA |
| Sleep duration | 0.0171 | 0.00683 | 0.0124 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.104 | 0.0418 | 0.013 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0542 | 0.0231 | 0.0188 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | 0.144 | 0.0636 | 0.0233 | Wald ratio | 1 | cis | NA |
| Serum creatinine (eGFRcrea) | -0.0071 | 0.00323 | 0.0278 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | -0.177 | 0.0818 | 0.0302 | Wald ratio | 1 | cis | NA |
| …and 88 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
71 association rows across 50 traits (62 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating DCBLD2 levels (id: OID01005_OID21474) | 5e-333 | rs190637453 | 3 | GCST90860231 | no MR -> candidate analysis |
| Circulating DCBLD2 levels (id: OID01376_OID21474) | 2e-332 | rs190637453 | 3 | GCST90860564 | no MR -> candidate analysis |
| Blood protein levels | 5e-331 | rs3796133 | 2 | GCST006585 | no MR -> candidate analysis |
| Type 2 lactosamine alpha-2,3-sialyltransferase levels (ST3GA | 2e-320 | rs140620086 | 1 | GCST90243193 | no MR -> candidate analysis |
| Type 2 lactosamine alpha-2,3-sialyltransferase levels | 6e-239 | rs10589669 | 1 | GCST90249754 | no MR -> candidate analysis |
| SIGLEC9 protein levels | 4e-156 | rs62278488 | 5 | GCST90470637 | no MR -> candidate analysis |
| ICAM2 protein levels | 2e-94 | rs540295212 | 6 | GCST90469499 | no MR -> candidate analysis |
| Circulating TYRO3 levels | 1e-61 | rs36160001 | 1 | GCST90860397 | no MR -> candidate analysis |
| Circulating TIE1 levels | 3e-51 | rs1983009 | 1 | GCST90860467 | no MR -> candidate analysis |
| TNFSF8 protein levels | 7e-42 | rs34860591 | 1 | GCST90470923 | no MR -> candidate analysis |
| CD33 protein levels | 1e-40 | rs11552978 | 1 | GCST90468625 | no MR -> candidate analysis |
| PDCD1LG2 protein levels | 2e-38 | rs202190925 | 4 | GCST90470180 | no MR -> candidate analysis |
| …and 38 more traits (see JSON) |
Top diseases by Open Targets association (of 392 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.582 | — | common-variant locus | no MR -> candidate analysis |
| open-angle glaucoma | 0.52 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.494 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| spontaneous abortion | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| iron metabolism disease | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| heart disorder | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| glaucoma | 0.397 | — | common-variant locus | MR: beta=-0.185, p=0.0367 (cis) |
| Abnormality of refraction | 0.355 | — | common-variant locus | no MR -> candidate analysis |
| pernicious anemia | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| metabolic disease | 0.329 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.31 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=5.7e-11, LOEUF=0.78 — LoF-tolerant |
| GWAS Catalog | 146 unique SNPs / 380 rows |
| ClinVar | 130 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 392 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘DCBLD2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 130 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 50 traits by best p-value, aggregated from 71 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q96PD2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000057019/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/DCBLD2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DCBLD2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DCBLD2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DCBLD2 — GWAS Catalog search API (live; release not exposed)