MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Eye problems or disorders: Cataract |
-0.342 |
0.107 |
0.00138 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gout |
0.25 |
0.0904 |
0.00562 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Diabetes related eye disease |
0.34 |
0.127 |
0.00742 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
-0.208 |
0.0822 |
0.0116 |
Wald ratio |
1 |
cis |
NA |
| Large vessel disease |
0.508 |
0.208 |
0.0146 |
Wald ratio |
1 |
cis |
NA |
| 2hr glucose |
-0.258 |
0.11 |
0.0188 |
Wald ratio |
1 |
cis |
NA |
| Low grade serous ovarian cancer |
-0.566 |
0.27 |
0.0358 |
Wald ratio |
1 |
cis |
NA |
| Red blood cell count |
-0.0252 |
0.0121 |
0.0365 |
Wald ratio |
1 |
cis |
NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis |
1.84 |
0.949 |
0.053 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
-69.5 |
36.2 |
0.0551 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
25.2 |
13.5 |
0.0629 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin |
0.104 |
0.0565 |
0.0665 |
Wald ratio |
1 |
cis |
NA |
| …and 90 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3535_84_1 |
DKK1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
34 association rows across 28 traits (31 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| DKK1/PDGFA protein level ratio |
2e-196 |
rs7093925 |
1 |
GCST90314475 |
no MR -> candidate analysis |
| DKK1/VEGFC protein level ratio |
1e-195 |
rs7093925 |
1 |
GCST90314484 |
no MR -> candidate analysis |
| APP/DKK1 protein level ratio |
3e-187 |
rs7093925 |
1 |
GCST90313321 |
no MR -> candidate analysis |
| DKK1/SERPINE1 protein level ratio |
9e-173 |
rs7093925 |
1 |
GCST90314480 |
no MR -> candidate analysis |
| DKK1/SPARC protein level ratio |
1e-163 |
rs7093925 |
1 |
GCST90314481 |
no MR -> candidate analysis |
| CCN2/DKK1 protein level ratio |
3e-156 |
rs7093925 |
1 |
GCST90313710 |
no MR -> candidate analysis |
| ANGPT1/DKK1 protein level ratio |
3e-128 |
rs7093925 |
1 |
GCST90313263 |
no MR -> candidate analysis |
| CPXM1/DKK1 protein level ratio |
1e-116 |
rs7093925 |
1 |
GCST90314218 |
no MR -> candidate analysis |
| DKK1/PDGFB protein level ratio |
1e-107 |
rs7093925 |
1 |
GCST90314476 |
no MR -> candidate analysis |
| Circulating DKK1 levels |
1e-91 |
rs7097068 |
3 |
GCST90859805 |
no MR -> candidate analysis |
| DKK1/NID2 protein level ratio |
2e-81 |
rs7093925 |
1 |
GCST90314474 |
no MR -> candidate analysis |
| DKK1/VEGFA protein level ratio |
2e-70 |
rs7093925 |
1 |
GCST90314483 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2274 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.728 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial fibrillation |
0.636 |
— |
common-variant locus |
no MR -> candidate analysis |
| Arnold-Chiari malformation type I |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| androgenetic alopecia |
0.431 |
— |
common-variant locus |
no MR -> candidate analysis |
| bone fracture |
0.408 |
— |
common-variant locus |
no MR -> candidate analysis |
| malunion fracture |
0.409 |
— |
common-variant locus |
no MR -> candidate analysis |
| radius fracture |
0.306 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulna fracture |
0.306 |
— |
common-variant locus |
no MR -> candidate analysis |
| Pilonidal abscess |
0.295 |
— |
common-variant locus |
no MR -> candidate analysis |
| spermatocele |
0.203 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (Dickkopf-related protein 1) |
| gnomAD constraint |
pLI=5.3e-05, LOEUF=1.03 — LoF-tolerant |
| GWAS Catalog |
35 unique SNPs / 62 rows |
| ClinVar |
68 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2274 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DKK1’ and resolved to ‘Dickkopf-related protein 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 68 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 34 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O94907 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000107984/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6024/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DKK1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DKK1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DKK1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DKK1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:17:18 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none