MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Ovarian cancer | 0.117 | 0.0369 | 0.00146 | Wald ratio | 1 | cis | NA |
| Birth weight | -0.0289 | 0.0102 | 0.00446 | Wald ratio | 1 | cis | NA |
| High grade serous ovarian cancer | 0.124 | 0.0443 | 0.00493 | Wald ratio | 1 | cis | NA |
| Weight | -0.0139 | 0.00553 | 0.0118 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0379 | 0.0168 | 0.0243 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0137 | 0.00626 | 0.029 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | -0.133 | 0.0634 | 0.0356 | Wald ratio | 1 | cis | NA |
| Eczema | 0.104 | 0.0521 | 0.0458 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.0642 | 0.0341 | 0.0598 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | 0.123 | 0.0662 | 0.0625 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: psoriasis | -0.123 | 0.067 | 0.0668 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.0836 | 0.0463 | 0.0709 | Wald ratio | 1 | cis | NA |
| …and 64 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
40 association rows across 29 traits (20 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein DKK2 | 1e-164 | rs114497723 | 1 | GCST90089488 | no MR -> candidate analysis |
| Blood protein levels | 2e-83 | rs77571736 | 1 | GCST006585 | no MR -> candidate analysis |
| Male-pattern baldness | 2e-33 | rs76067940 | 7 | GCST007020 | no MR -> candidate analysis |
| Balding type 1 | 2e-25 | rs76067940 | 2 | GCST007038 | no MR -> candidate analysis |
| Circulating CST6 levels | 3e-19 | rs7663915 | 2 | GCST90860620 | no MR -> candidate analysis |
| CST6 protein levels | 5e-19 | rs7663915 | 1 | GCST90468896 | no MR -> candidate analysis |
| Circulating DSG4 levels | 3e-11 | rs10023574 | 1 | GCST90860253 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 6e-11 | rs76067940 | 1 | GCST90095129 | no MR -> candidate analysis |
| Vaginal microbiome relative abundance (s_Lactobacillus mulie | 3e-10 | rs75042393 | 2 | GCST90027014 | no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) | 3e-10 | rs979775 x rs11933230 | 1 | GCST010340 | no MR -> candidate analysis |
| Anxiety x Caesarean-section interaction | 1e-9 | rs13137764 | 1 | GCST90275370 | no MR -> candidate analysis |
| Cortical surface area | 2e-8 | rs76067940 | 1 | GCST90091060 | no MR -> candidate analysis |
| …and 17 more traits (see JSON) |
Top diseases by Open Targets association (of 783 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| androgenetic alopecia | 0.747 | — | common-variant locus | no MR -> candidate analysis |
| alopecia | 0.64 | — | common-variant locus | no MR -> candidate analysis |
| benign prostatic hyperplasia | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| Abnormal nasolacrimal system morphology | 0.52 | — | common-variant locus | no MR -> candidate analysis |
| intestinal obstruction | 0.52 | — | common-variant locus | no MR -> candidate analysis |
| Hyperhidrosis | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| Anxiety | 0.501 | — | common-variant locus | MR: beta=-0.0847, p=0.151 (cis) |
| cesarean section | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| respiratory tract infectious disorder | 0.405 | — | common-variant locus | no MR -> candidate analysis |
| asthma | 0.405 | — | common-variant locus | no MR -> candidate analysis |
| poisoning | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| vitiligo | 0.346 | — | common-variant locus | no MR -> candidate analysis |
| multiple sclerosis | 0.311 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.246 | — | common-variant locus | no MR -> candidate analysis |
| benign neoplasm of eye | 0.221 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.47, LOEUF=0.648 — LoF-tolerant |
| GWAS Catalog | 33 unique SNPs / 51 rows |
| ClinVar | 50 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 783 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘DKK2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 50 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 29 traits by best p-value, aggregated from 40 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9UBU2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000155011/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/DKK2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DKK2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DKK2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DKK2 — GWAS Catalog search API (live; release not exposed)