MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.33 |
0.0588 |
1.88e-08 |
Wald ratio |
1 |
trans |
NA |
| Lumbar spine bone mineral density |
0.0688 |
0.025 |
0.00585 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
-0.227 |
0.0839 |
0.00682 |
Wald ratio |
1 |
trans |
NA |
| Femoral neck bone mineral density |
0.0557 |
0.0214 |
0.00926 |
Wald ratio |
1 |
trans |
NA |
| Height |
0.0217 |
0.00841 |
0.0097 |
Wald ratio |
1 |
trans |
NA |
| Cigarettes smoked per day |
-0.6 |
0.235 |
0.0108 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries |
-0.253 |
0.108 |
0.0195 |
Wald ratio |
1 |
trans |
NA |
| Cardioembolic stroke |
0.21 |
0.091 |
0.021 |
Wald ratio |
1 |
trans |
NA |
| Fractured or broken bones in last 5 years |
-0.0498 |
0.023 |
0.0303 |
Wald ratio |
1 |
trans |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0128 |
0.00606 |
0.0342 |
Wald ratio |
1 |
trans |
NA |
| Crohn’s disease |
-0.0727 |
0.0362 |
0.0447 |
Wald ratio |
1 |
trans |
NA |
| Depressive symptoms |
-0.0203 |
0.0101 |
0.0455 |
Wald ratio |
1 |
trans |
NA |
| …and 94 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3365_7_2 |
Dkk-4 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
4 association rows across 3 traits (4 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Mean sphered cell volume (UKB data field 30270) |
5e-34 |
rs113111764 |
1 |
GCST90468089 |
no MR -> candidate analysis |
| Mean reticulocyte volume (UKB data field 30260) |
3e-29 |
rs113111764 |
2 |
GCST90468088 |
no MR -> candidate analysis |
| Dickkopf-related protein 4 levels |
3e-14 |
rs77736087 |
1 |
GCST90059943 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 120 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| osteoarthritis |
0.415 |
— |
common-variant locus |
MR: beta=-0.137, p=0.0903 (trans) |
| Abnormality of the skeletal system |
0.077 |
— |
common-variant locus |
no MR -> candidate analysis |
| tonsillitis |
0.076 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian dysfunction |
0.064 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis, knee |
0.059 |
— |
common-variant locus |
MR: beta=-0.137, p=0.0903 (trans) |
| Loss of consciousness |
0.038 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=4.4e-06, LOEUF=1.59 — LoF-tolerant |
| GWAS Catalog |
31 unique SNPs / 59 rows |
| ClinVar |
103 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 120 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘DKK4’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 103 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 3 of 3 traits by best p-value, aggregated from 4 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UBT3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104371/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/DKK4 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DKK4 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DKK4%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DKK4 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:17:55 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none