MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis | 2.44 | 0.229 | 1.86e-26 | Wald ratio | 1 | trans | NA |
| LDL cholesterol | 0.156 | 0.0211 | 1.41e-13 | Wald ratio | 1 | trans | 1 |
| Diagnoses - main ICD10: K80 Cholelithiasis | 0.283 | 0.0566 | 5.77e-07 | Wald ratio | 1 | trans | NA |
| Total cholesterol | 0.102 | 0.0208 | 1.01e-06 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.176 | 0.0403 | 1.28e-05 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0918 | 0.0265 | 5.42e-04 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting | 0.347 | 0.123 | 0.00482 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter | 0.217 | 0.0825 | 0.00838 | Wald ratio | 1 | trans | NA |
| HDL cholesterol | -0.0538 | 0.0207 | 0.00924 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | -0.0222 | 0.00881 | 0.0118 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: depression | -0.0994 | 0.049 | 0.0427 | Wald ratio | 1 | trans | NA |
| Weight | -0.0182 | 0.00949 | 0.0544 | Wald ratio | 1 | trans | NA |
| …and 61 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
27 association rows across 15 traits (20 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| LAMB1 protein levels | 9e-23 | rs73195464 | 3 | GCST90469732 | no MR -> candidate analysis |
| NRCAM protein levels | 3e-20 | rs145468221 | 2 | GCST90470082 | no MR -> candidate analysis |
| Insomnia | 8e-13 | rs10254670 | 7 | GCST90131901 | no MR -> candidate analysis |
| Exostosis of jaw (PheCode 526.8) | 4e-11 | rs538989321 | 1 | GCST90480282 | no MR -> candidate analysis |
| Protein quantitative trait loci (liver) | 1e-9 | rs6971377 | 3 | GCST011427 | no MR -> candidate analysis |
| Body size at age 10 | 3e-9 | rs10953577 | 1 | GCST010989 | no MR -> candidate analysis |
| Educational attainment (years of education) | 6e-9 | rs78270331 | 2 | GCST006442 | no MR -> candidate analysis |
| Cerebellar grey matter morphology (MOSTest) | 6e-9 | rs7811819 | 1 | GCST90728589 | no MR -> candidate analysis |
| Hippocampus volume change rate x age interaction (1df) | 6e-8 | rs2215141 | 1 | GCST90128565 | no MR -> candidate analysis |
| Breast dense area | 1e-7 | rs138864371 | 1 | GCST90293091 | no MR -> candidate analysis |
| Hippocampus volume change rate x age interaction (2df) | 2e-7 | rs2215141 | 1 | GCST90128580 | no MR -> candidate analysis |
| Metabolite levels | 4e-7 | rs13231248 | 1 | GCST009391 | no MR -> candidate analysis |
| …and 3 more traits (see JSON) |
Top diseases by Open Targets association (of 178 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| insomnia | 0.271 | — | common-variant locus | no MR -> candidate analysis |
| crush injury | 0.236 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary vascular congestion | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| myopia | 0.186 | — | common-variant locus | no MR -> candidate analysis |
| polycythemia | 0.168 | — | common-variant locus | no MR -> candidate analysis |
| trauma complication | 0.124 | — | common-variant locus | no MR -> candidate analysis |
| exostosis | 0.113 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.088 | — | common-variant locus | no MR -> candidate analysis |
| musculoskeletal system disorder | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| coffee consumption | 0.059 | — | common-variant locus | no MR -> candidate analysis |
Of the 11 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.0029, LOEUF=1.01 — LoF-tolerant |
| GWAS Catalog | 30 unique SNPs / 48 rows |
| ClinVar | 67 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 178 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘DNAJB9’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 67 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 15 of 15 traits by best p-value, aggregated from 27 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9UBS3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000128590/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/DNAJB9 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DNAJB9 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DNAJB9%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DNAJB9 — GWAS Catalog search API (live; release not exposed)