MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Birth weight | 0.0648 | 0.0265 | 0.0146 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | 0.256 | 0.108 | 0.0175 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | 0.307 | 0.145 | 0.0343 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Other bones | 0.132 | 0.0633 | 0.0377 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | 0.182 | 0.0894 | 0.0414 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: iron deficiency anaemia | 0.34 | 0.167 | 0.0415 | Wald ratio | 1 | cis | NA |
| Caudate volume | 74.2 | 37.1 | 0.0457 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | 0.0501 | 0.0272 | 0.0652 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: uterine fibroids | 0.199 | 0.111 | 0.0727 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.195 | 0.112 | 0.0825 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.252 | 0.147 | 0.0864 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.184 | 0.109 | 0.0909 | Wald ratio | 1 | cis | NA |
| …and 55 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
121 association rows across 93 traits (65 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating DNER levels | 5e-491 | rs62193248 | 7 | GCST90860417 | no MR -> candidate analysis |
| DNER protein levels | 1e-159 | rs35565740 | 6 | GCST90469019 | no MR -> candidate analysis |
| Delta and Notch-like epidermal growth factor-related recepto | 1e-67 | rs62193248 | 5 | GCST90274785 | no MR -> candidate analysis |
| Lung function (FEV1/FVC) | 4e-26 | rs1862106 | 3 | GCST90244094 | no MR -> candidate analysis |
| Height | 2e-23 | rs6761377 | 1 | GCST90245848 | no MR -> candidate analysis |
| Creatinine levels | 1e-18 | rs62190394 | 1 | GCST90662902 | no MR -> candidate analysis |
| Arm fat percentage left (UKB data field 23123) | 1e-17 | rs62190394 | 1 | GCST90468157 | no MR -> candidate analysis |
| Body mass index | 7e-17 | rs62190394 | 8 | GCST007039 | no MR -> candidate analysis |
| Predicted visceral adipose tissue | 2e-16 | rs62190394 | 1 | GCST008744 | no MR -> candidate analysis |
| FEV1 FVC ratio Z score (UKB data field 20258) | 1e-15 | rs207667 | 1 | GCST90468165 | no MR -> candidate analysis |
| Serum levels of protein DNER | 2e-14 | rs34661502 | 1 | GCST90090814 | no MR -> candidate analysis |
| Whole body fat mass (UKB data field 23100) | 3e-14 | rs62190394 | 2 | GCST90428121 | no MR -> candidate analysis |
| …and 81 more traits (see JSON) |
Top diseases by Open Targets association (of 1635 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| breast carcinoma | 0.496 | — | common-variant locus | no MR -> candidate analysis |
| knee fracture | 0.512 | — | common-variant locus | no MR -> candidate analysis |
| tongue cancer | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| respiratory tract infectious disorder | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| cardiomyopathy | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.441 | — | common-variant locus | no MR -> candidate analysis |
| Her2-receptor negative breast cancer | 0.434 | — | common-variant locus | no MR -> candidate analysis |
| response to antineoplastic agent | 0.434 | — | common-variant locus | no MR -> candidate analysis |
| progesterone-receptor positive breast cancer | 0.434 | — | common-variant locus | no MR -> candidate analysis |
| estrogen-receptor positive breast cancer | 0.434 | — | common-variant locus | no MR -> candidate analysis |
| Abnormal pupillary function | 0.414 | — | common-variant locus | no MR -> candidate analysis |
| tooth disorder | 0.362 | — | common-variant locus | no MR -> candidate analysis |
| Hirsutism | 0.247 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Delta and Notch-like epidermal growth factor-related receptor) |
| gnomAD constraint | pLI=0.11, LOEUF=0.565 — LoF-tolerant |
| GWAS Catalog | 104 unique SNPs / 210 rows |
| ClinVar | 186 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1635 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DNER’ and resolved to ‘Delta and Notch-like epidermal growth factor-related receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 186 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 93 traits by best p-value, aggregated from 121 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8NFT8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000187957/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5291567/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DNER — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DNER — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DNER%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DNER — GWAS Catalog search API (live; release not exposed)