MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Schizophrenia | 0.104 | 0.0348 | 0.00278 | Wald ratio | 1 | cis | NA |
| Amyotrophic lateral sclerosis | 0.132 | 0.0572 | 0.0214 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | -0.0535 | 0.0244 | 0.0282 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | -0.314 | 0.153 | 0.0397 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.0618 | 0.0357 | 0.0837 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.0488 | 0.0321 | 0.128 | Wald ratio | 1 | cis | NA |
| Neuroticism | -0.0192 | 0.0128 | 0.134 | Wald ratio | 1 | cis | NA |
| Thalamus volume | 28.3 | 20.5 | 0.169 | Wald ratio | 1 | cis | NA |
| Pallidum volume | 8.37 | 6.27 | 0.181 | Wald ratio | 1 | cis | NA |
| Putamen volume | 25.3 | 19.7 | 0.2 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0374 | 0.0371 | 0.313 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | -0.0128 | 0.0128 | 0.317 | Wald ratio | 1 | cis | NA |
| …and 5 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
191 association rows across 128 traits (177 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating DPEP1 levels | 1e-2323 | rs9673342 | 3 | GCST90860743 | no MR -> candidate analysis |
| Urine prolylglycine levels in chronic kidney disease | 9e-369 | rs2434858 | 1 | GCST90265875 | no MR -> candidate analysis |
| Dipeptidase 1 levels | 8e-366 | rs409170 | 3 | GCST90247341 | no MR -> candidate analysis |
| Hair color | 1e-300 | rs12930346 | 1 | GCST007082 | no MR -> candidate analysis |
| DPEP1 protein levels | 2e-278 | rs76820443 | 3 | GCST90469030 | no MR -> candidate analysis |
| Cys-gly, oxidized levels | 9e-259 | rs409170 | 3 | GCST90245155 | no MR -> candidate analysis |
| Metabolite levels (cys-gly, oxidized) | 2e-191 | rs1126464 | 5 | GCST90299957 | no MR -> candidate analysis |
| Serum metabolite levels | 2e-122 | rs1126464 | 4 | GCST012020 | no MR -> candidate analysis |
| Plasma cys-gly, oxidized levels in chronic kidney disease | 2e-114 | rs409170 | 1 | GCST90264973 | no MR -> candidate analysis |
| Urine N-lactoyl leucine levels in chronic kidney disease | 2e-110 | rs2460451 | 1 | GCST90265629 | no MR -> candidate analysis |
| Urinary metabolite levels in chronic kidney disease | 1e-99 | rs420332 | 4 | GCST009733 | no MR -> candidate analysis |
| Serum levels of protein DPEP1 | 5e-80 | rs258341 | 1 | GCST90090302 | no MR -> candidate analysis |
| …and 116 more traits (see JSON) |
Top diseases by Open Targets association (of 212 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| osteoarthritis | 0.832 | — | common-variant locus | no MR -> candidate analysis |
| skin cancer | 0.636 | — | common-variant locus | no MR -> candidate analysis |
| skin neoplasm | 0.573 | — | common-variant locus | no MR -> candidate analysis |
| actinic keratosis | 0.551 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.525 | — | common-variant locus | no MR -> candidate analysis |
| Pain | 0.506 | — | common-variant locus | no MR -> candidate analysis |
| carpal tunnel syndrome | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| chronic kidney disease | 0.476 | — | common-variant locus | no MR -> candidate analysis |
| myasthenia gravis | 0.464 | — | common-variant locus | no MR -> candidate analysis |
| hyperuricemia | 0.43 | — | common-variant locus | no MR -> candidate analysis |
| melanoma | 0.35 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.33 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.33 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.206 | — | common-variant locus | no MR -> candidate analysis |
| essential hypertension | 0.17 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 2 known modulators (Dipeptidase 1) |
| gnomAD constraint | pLI=4.2e-20, LOEUF=1.5 — LoF-tolerant |
| GWAS Catalog | 196 unique SNPs / 523 rows |
| ClinVar | 139 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 212 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DPEP1’ and resolved to ‘Dipeptidase 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 139 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 128 traits by best p-value, aggregated from 191 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P16444 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000015413/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1989/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DPEP1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DPEP1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DPEP1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DPEP1 — GWAS Catalog search API (live; release not exposed)