MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Invasive mucinous ovarian cancer | 0.5 | 0.259 | 0.0537 | Wald ratio | 1 | trans | NA |
| Forearm bone mineral density | 0.153 | 0.0908 | 0.0911 | Wald ratio | 1 | trans | NA |
| Hippocampus volume | -51.4 | 31 | 0.0973 | Wald ratio | 1 | trans | NA |
| Nucleus accumbens volume | -11.7 | 7.27 | 0.106 | Wald ratio | 1 | trans | NA |
| Pallidum volume | -19.9 | 12.6 | 0.114 | Wald ratio | 1 | trans | NA |
| Putamen volume | -61.3 | 39.4 | 0.12 | Wald ratio | 1 | trans | NA |
| Depressive symptoms | 0.0365 | 0.0258 | 0.157 | Wald ratio | 1 | trans | NA |
| Amygdala volume | -18.8 | 15.5 | 0.226 | Wald ratio | 1 | trans | NA |
| Thalamus volume | -48.2 | 41.3 | 0.244 | Wald ratio | 1 | trans | NA |
| Lung cancer | 0.12 | 0.121 | 0.321 | Wald ratio | 1 | trans | NA |
| Primary sclerosing cholangitis | 0.173 | 0.176 | 0.325 | Wald ratio | 1 | trans | NA |
| Low grade serous ovarian cancer | 0.325 | 0.332 | 0.328 | Wald ratio | 1 | trans | NA |
| …and 7 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
158 association rows across 129 traits (140 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| DPP4 protein levels | 2e-272 | rs13015258 | 4 | GCST90469033 | no MR -> candidate analysis |
| Circulating DPP4 levels | 8e-268 | rs13015258 | 2 | GCST90860464 | no MR -> candidate analysis |
| DPP4/ITGB1 protein level ratio | 1e-154 | rs35128070 | 1 | GCST90314540 | no MR -> candidate analysis |
| ANPEP/DPP4 protein level ratio | 4e-109 | rs2193681 | 1 | GCST90313273 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 8e-68 | rs2284871 | 1 | GCST90095129 | no MR -> candidate analysis |
| Smoking initiation | 2e-38 | rs2909449 | 4 | GCST90243968 | no MR -> candidate analysis |
| Vertex-wise cortical thickness | 1e-37 | rs4140685 | 1 | GCST90095131 | no MR -> candidate analysis |
| Vertex-wise cortical surface area | 1e-34 | rs2160927 | 1 | GCST90095130 | no MR -> candidate analysis |
| Left hippocampal volume (tail) | 9e-34 | rs6432708 | 1 | GCST90267907 | no MR -> candidate analysis |
| Left hippocampal volume | 2e-32 | rs2268894 | 1 | GCST90267908 | no MR -> candidate analysis |
| Right hippocampal volume | 3e-31 | rs2268894 | 1 | GCST90267930 | no MR -> candidate analysis |
| Self-reported math ability (MTAG) | 1e-30 | rs2268894 | 1 | GCST006569 | no MR -> candidate analysis |
| …and 117 more traits (see JSON) |
Top diseases by Open Targets association (of 1465 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| chronic kidney disease | 0.489 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.712 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.674 | — | common-variant locus | no MR -> candidate analysis |
| asthma | 0.594 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.089 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.582 | — | common-variant locus | no MR -> candidate analysis |
| kidney failure | 0.542 | — | common-variant locus | no MR -> candidate analysis |
| rheumatoid arthritis | 0.46 | — | common-variant locus | no MR -> candidate analysis |
| Microscopic hematuria | 0.489 | — | common-variant locus | no MR -> candidate analysis |
| autism spectrum disorder | 0.471 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.471 | — | common-variant locus | no MR -> candidate analysis |
Of the 11 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 19 known modulators (Dipeptidyl peptidase 4) |
| gnomAD constraint | pLI=4.9e-24, LOEUF=0.902 — LoF-tolerant |
| GWAS Catalog | 107 unique SNPs / 242 rows |
| ClinVar | 169 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1465 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DPP4’ and resolved to ‘Dipeptidyl peptidase 4’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 169 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 129 traits by best p-value, aggregated from 158 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P27487 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000197635/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL284/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DPP4 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DPP4 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DPP4%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DPP4 — GWAS Catalog search API (live; release not exposed)