Protein Dossier — DPP7 (Dipeptidyl peptidase 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypertension |
-0.0433 |
0.0135 |
0.00132 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
-0.107 |
0.0408 |
0.00891 |
Wald ratio |
1 |
cis |
NA |
| Clear cell ovarian cancer |
0.305 |
0.137 |
0.0261 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: J33 Nasal polyp |
0.194 |
0.0915 |
0.0339 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: arthritis (nos) |
0.156 |
0.0751 |
0.0376 |
Wald ratio |
1 |
cis |
NA |
| Hirschsprung’s disease |
-0.962 |
0.473 |
0.042 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
-0.125 |
0.0623 |
0.0444 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.119 |
0.0597 |
0.0461 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
-0.163 |
0.0847 |
0.0542 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
-0.0228 |
0.0121 |
0.0592 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse |
0.165 |
0.0879 |
0.0606 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0401 |
0.0221 |
0.0699 |
Wald ratio |
1 |
cis |
NA |
| …and 57 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3608_12_1 |
DPP2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
23 association rows across 19 traits (23 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| DPP7/SIAE protein level ratio |
1e-1546 |
rs10747049 |
1 |
GCST90314549 |
no MR -> candidate analysis |
| DPP7/TPP1 protein level ratio |
7e-1468 |
rs10747049 |
1 |
GCST90314550 |
no MR -> candidate analysis |
| DPP7/MCFD2 protein level ratio |
3e-1460 |
rs10747049 |
1 |
GCST90314547 |
no MR -> candidate analysis |
| DPP7/GLB1 protein level ratio |
9e-1338 |
rs10747049 |
1 |
GCST90314545 |
no MR -> candidate analysis |
| ARSA/DPP7 protein level ratio |
3e-1288 |
rs10747049 |
1 |
GCST90313353 |
no MR -> candidate analysis |
| ARSB/DPP7 protein level ratio |
3e-1277 |
rs10747049 |
1 |
GCST90313358 |
no MR -> candidate analysis |
| CREG1/DPP7 protein level ratio |
6e-1263 |
rs10747049 |
1 |
GCST90314248 |
no MR -> candidate analysis |
| DPP7/PLA2G15 protein level ratio |
1e-1249 |
rs10747049 |
1 |
GCST90314548 |
no MR -> candidate analysis |
| CANT1/DPP7 protein level ratio |
3e-1168 |
rs10747049 |
1 |
GCST90313614 |
no MR -> candidate analysis |
| DPP7/LGMN protein level ratio |
7e-1110 |
rs10747049 |
1 |
GCST90314546 |
no MR -> candidate analysis |
| DPP7/VSIR protein level ratio |
2e-1071 |
rs10747049 |
1 |
GCST90314551 |
no MR -> candidate analysis |
| Dipeptidyl peptidase 2 levels |
3e-513 |
rs10747049 |
5 |
GCST90247349 |
no MR -> candidate analysis |
| …and 7 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 115 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.067 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Dipeptidyl peptidase 2) |
| gnomAD constraint |
pLI=8.5e-31, LOEUF=1.53 — LoF-tolerant |
| GWAS Catalog |
71 unique SNPs / 142 rows |
| ClinVar |
278 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 115 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘DPP7’ and resolved to ‘Dipeptidyl peptidase 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 278 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 19 of 19 traits by best p-value, aggregated from 23 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UHL4 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000176978/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3976/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/DPP7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DPP7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DPP7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DPP7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:20:03 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none