Protein Dossier — DPT (Dermatopontin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Body mass index (BMI) |
-0.0225 |
0.00587 |
1.24e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
-0.166 |
0.0493 |
7.42e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
-0.0929 |
0.0312 |
0.00287 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Diabetes related eye disease |
0.176 |
0.0633 |
0.00542 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0233 |
0.00868 |
0.00728 |
Wald ratio |
1 |
cis |
NA |
| Weight |
-0.0137 |
0.00519 |
0.00803 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0741 |
0.0289 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
0.124 |
0.0492 |
0.0118 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
-0.0241 |
0.00963 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.0119 |
0.00482 |
0.0133 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: migraine |
-0.0893 |
0.0372 |
0.0162 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
-0.101 |
0.0438 |
0.0207 |
Wald ratio |
1 |
cis |
NA |
| …and 74 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4979_34_2 |
DERM |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
84 association rows across 39 traits (75 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Dermatopontin levels |
8e-211 |
rs1018454 |
6 |
GCST90247265 |
no MR -> candidate analysis |
| DPT protein levels |
2e-207 |
rs78032017 |
13 |
GCST90469036 |
no MR -> candidate analysis |
| XCL1 protein levels |
4e-128 |
rs116047858 |
8 |
GCST90471081 |
no MR -> candidate analysis |
| Electrocardiogram morphology (amplitude at temporal datapoin |
5e-68 |
rs531706 |
16 |
GCST010796 |
no MR -> candidate analysis |
| Dermatopontin levels (DPT.4979.34.2) |
8e-67 |
rs1018454 |
1 |
GCST90240890 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein DPT levels |
2e-63 |
rs607484 |
1 |
GCST90944747 |
no MR -> candidate analysis |
| Serum levels of protein DPT |
3e-63 |
rs1018454 |
1 |
GCST90088840 |
no MR -> candidate analysis |
| Blood protein levels |
7e-34 |
rs1018454 |
1 |
GCST006585 |
no MR -> candidate analysis |
| ECG latent space |
3e-25 |
rs635954 |
1 |
GCST90250897 |
no MR -> candidate analysis |
| neutrophil (fraction, minimum, inv-norm transformed) |
3e-21 |
rs1337742 |
1 |
GCST90479715 |
no MR -> candidate analysis |
| ECG cardiac MRI latent space |
2e-19 |
rs545833 |
1 |
GCST90250896 |
no MR -> candidate analysis |
| Thyroid stimulating hormone levels |
1e-18 |
rs580360 |
1 |
GCST90572789 |
no MR -> candidate analysis |
| …and 27 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 749 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Sensorineural hearing impairment |
0.663 |
— |
common-variant locus |
no MR -> candidate analysis |
| hearing loss disorder |
0.647 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypothyroidism |
0.645 |
— |
common-variant locus |
MR: beta=-0.0588, p=0.0339 (cis) |
| atrial fibrillation |
0.577 |
— |
common-variant locus |
MR: beta=0.124, p=0.0118 (cis) |
| deep vein thrombosis |
0.571 |
— |
common-variant locus |
no MR -> candidate analysis |
| Progressive sensorineural hearing impairment |
0.559 |
— |
established (curated) |
no MR -> candidate analysis |
| COVID-19 |
0.553 |
— |
common-variant locus |
no MR -> candidate analysis |
| severe acute respiratory syndrome |
0.553 |
— |
common-variant locus |
no MR -> candidate analysis |
| restless legs syndrome |
0.529 |
— |
common-variant locus |
no MR -> candidate analysis |
| phobic disorder |
0.484 |
— |
common-variant locus |
no MR -> candidate analysis |
| septic shock |
0.484 |
— |
common-variant locus |
no MR -> candidate analysis |
| blood coagulation disease |
0.476 |
— |
common-variant locus |
no MR -> candidate analysis |
| lower respiratory tract disorder |
0.445 |
— |
common-variant locus |
no MR -> candidate analysis |
| placenta praevia |
0.429 |
— |
common-variant locus |
no MR -> candidate analysis |
| venous thromboembolism |
0.412 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.9e-05, LOEUF=0.968 — LoF-tolerant |
| GWAS Catalog |
80 unique SNPs / 154 rows |
| ClinVar |
69 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 749 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘DPT’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 69 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 39 traits by best p-value, aggregated from 84 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q07507 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000143196/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/DPT — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/DPT — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=DPT%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/DPT — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:20:16 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none