CausalSentinel

Protein Dossier — DUSP13 (Dual specificity protein phosphatase 13B)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Cough on most days	-0.102	0.0337	0.00259	Inverse variance weighted	2	cis	NA
Cough on most days	-0.102	0.0337	0.00259	Inverse variance weighted	2	trans	NA
HDL cholesterol	0.0478	0.016	0.00289	Wald ratio	1	cis	NA
Childhood intelligence	0.124	0.0431	0.00393	Wald ratio	1	cis	NA
Sodium in urine	-0.0161	0.00584	0.00598	Inverse variance weighted	2	cis	NA
Sodium in urine	-0.0161	0.00584	0.00598	Inverse variance weighted	2	trans	NA
Diagnoses - main ICD10: R55 Syncope and collapse	-0.209	0.0782	0.0076	Inverse variance weighted	2	cis	NA
Diagnoses - main ICD10: R55 Syncope and collapse	-0.209	0.0782	0.0076	Inverse variance weighted	2	trans	NA
Creatinine (enzymatic) in urine	-0.0146	0.00568	0.0102	Inverse variance weighted	2	cis	NA
Creatinine (enzymatic) in urine	-0.0146	0.00568	0.0102	Inverse variance weighted	2	trans	NA
Non-cancer illness code self-reported: emphysema or chronic bronchitis	-0.139	0.0593	0.0187	Inverse variance weighted	2	cis	NA
Non-cancer illness code self-reported: emphysema or chronic bronchitis	-0.139	0.0593	0.0187	Inverse variance weighted	2	trans	NA
…and 157 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

No GWAS Catalog associations mapped to this gene.

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

Top diseases by Open Targets association (of 47 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.

Disease	genetic assoc.	burden (ExWAS)	causal status	MR status
atrial fibrillation	0.732	—	common-variant locus	no MR -> candidate analysis
major depressive disorder	0.683	—	common-variant locus	MR: beta=-0.149, p=0.0372 (cis)
coronary artery disorder	0.625	—	common-variant locus	no MR -> candidate analysis
peripheral arterial disease	0.625	—	common-variant locus	no MR -> candidate analysis
smoking initiation	0.574	—	common-variant locus	no MR -> candidate analysis
insomnia	0.55	—	common-variant locus	no MR -> candidate analysis
diabetes mellitus	0.082	—	common-variant locus	no MR -> candidate analysis
atrial flutter	0.058	—	common-variant locus	no MR -> candidate analysis
type 2 diabetes mellitus	0.047	—	common-variant locus	no MR -> candidate analysis
hypertensive disorder	0.037	—	common-variant locus	no MR -> candidate analysis
coronary atherosclerosis	0.033	—	common-variant locus	no MR -> candidate analysis

Of the 11 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	not available
GWAS Catalog	no mapped SNPs
ClinVar	no records
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 47 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘DUSP13’.
• gnomad — No gnomAD constraint data.
• gwas — No GWAS Catalog SNPs mapped to this gene.
• clinvar — No ClinVar records.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — No GWAS Catalog associations mapped to this gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/Q9UII6 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000079393/associations — Open Targets data release 26.06

Provenance

• Generated: 2026-08-14T02:21:02 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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