Protein Dossier — F10 (Coagulation factor X)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: K35 Acute appendicitis |
0.38 |
0.0967 |
8.35e-05 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
-0.0294 |
0.00988 |
0.00291 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.0276 |
0.00973 |
0.00454 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: joint disorder |
0.276 |
0.109 |
0.0116 |
Wald ratio |
1 |
cis |
NA |
| Neuroticism |
0.0219 |
0.00947 |
0.0207 |
Inverse variance weighted |
2 |
trans |
NA |
| Neuroticism |
0.0219 |
0.00947 |
0.0207 |
Inverse variance weighted |
2 |
cis |
NA |
| Diagnoses - main ICD10: N81 Female genital prolapse |
-0.211 |
0.102 |
0.0381 |
Wald ratio |
1 |
cis |
NA |
| Weight |
-0.0178 |
0.0086 |
0.0382 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.272 |
0.132 |
0.0392 |
Wald ratio |
1 |
cis |
NA |
| Triglycerides |
-0.0302 |
0.0159 |
0.0571 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
-17.1 |
9.33 |
0.0664 |
Wald ratio |
1 |
trans |
NA |
| HOMA-B |
-0.0325 |
0.0186 |
0.0801 |
Wald ratio |
1 |
cis |
NA |
| …and 98 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3077_66_2 |
Coagulation Factor Xa |
Suhre K |
2019 |
prot-c-4878_3_1 |
Coagulation Factor X |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
59 association rows across 28 traits (52 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Protein Z-dependent protease inhibitor levels |
4e-370 |
rs559054 |
2 |
GCST90249198 |
no MR -> candidate analysis |
| Dual specificity mitogen-activated protein kinase kinase 2 l |
6e-259 |
rs559054 |
2 |
GCST90247301 |
no MR -> candidate analysis |
| F7 protein levels |
7e-177 |
rs9549675 |
5 |
GCST90469171 |
no MR -> candidate analysis |
| F10 protein levels |
2e-146 |
rs547138 |
5 |
GCST90469163 |
no MR -> candidate analysis |
| PROZ protein levels |
1e-110 |
rs559054 |
3 |
GCST90453206 |
no MR -> candidate analysis |
| Protein Z-dependent protease inhibitor levels (SERPINA10.131 |
6e-100 |
rs559054 |
2 |
GCST90242530 |
no MR -> candidate analysis |
| Coagulation Factor VII levels |
6e-65 |
rs474671 |
4 |
GCST90100839 |
no MR -> candidate analysis |
| Circulating F7 levels |
2e-63 |
rs3212991 |
1 |
GCST90860440 |
no MR -> candidate analysis |
| Coagulation Factor X levels |
2e-51 |
rs547138 |
2 |
GCST90247101 |
no MR -> candidate analysis |
| Coagulation factor Xa levels |
8e-50 |
rs547138 |
5 |
GCST90247102 |
no MR -> candidate analysis |
| SERPINA10 protein levels |
1e-38 |
rs559054 |
2 |
GCST90453399 |
no MR -> candidate analysis |
| Prothrombin time |
7e-30 |
rs563964 |
4 |
GCST90104196 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 628 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| factor X deficiency |
0.96 |
— |
established (curated) |
no MR -> candidate analysis |
| congenital factor X deficiency |
0.819 |
— |
established (curated) |
no MR -> candidate analysis |
| venous thromboembolism |
0.832 |
— |
common-variant locus |
no MR -> candidate analysis |
| pulmonary embolism |
0.566 |
— |
common-variant locus |
MR: beta=0.136, p=0.154 (cis) |
| atrial fibrillation |
0.053 |
— |
common-variant locus |
no MR -> candidate analysis |
| Thrombocytopenia |
0.491 |
— |
established (curated) |
no MR -> candidate analysis |
| Thromboembolism |
0.317 |
— |
common-variant locus |
no MR -> candidate analysis |
| blood coagulation disease |
0.055 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormal bleeding |
0.584 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 9 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
13 known modulators (Coagulation factor X) |
| gnomAD constraint |
pLI=1.8e-08, LOEUF=1.07 — LoF-tolerant |
| GWAS Catalog |
111 unique SNPs / 260 rows |
| ClinVar |
303 records; 8 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 628 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘F10’ and resolved to ‘Coagulation factor X’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 303 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 59 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P00742 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000126218/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL244/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/F10 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/F10 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=F10%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/F10 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:30:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none