MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: ankylosing spondylitis | 0.33 | 0.0984 | 7.93e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K43 Ventral hernia | -0.451 | 0.175 | 0.00995 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | -0.0248 | 0.011 | 0.0244 | Wald ratio | 1 | cis | NA |
| Height | 0.0195 | 0.00881 | 0.0265 | Wald ratio | 1 | cis | NA |
| Serum creatinine (eGFRcrea) | 0.00551 | 0.00253 | 0.0297 | Wald ratio | 1 | cis | NA |
| Inflammatory bowel disease | -0.0669 | 0.0308 | 0.0298 | Wald ratio | 1 | cis | NA |
| Thyroid cancer | -0.552 | 0.257 | 0.0319 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate | -0.188 | 0.0908 | 0.0385 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation | 0.0937 | 0.0455 | 0.0394 | Wald ratio | 1 | cis | NA |
| Crohn’s disease | -0.0765 | 0.0372 | 0.0395 | Wald ratio | 1 | cis | NA |
| Serum cystatin C (eGFRcys) | 0.0118 | 0.00578 | 0.0406 | Wald ratio | 1 | cis | NA |
| Neuroticism | -0.022 | 0.011 | 0.0455 | Wald ratio | 1 | cis | NA |
| …and 93 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
121 association rows across 62 traits (106 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating FAS levels | 8e-572 | rs7911226 | 3 | GCST90859960 | no MR -> candidate analysis |
| Circulating FASLG levels (id: OID00694_OID20665) | 8e-526 | rs12775501 | 8 | GCST90860038 | no MR -> candidate analysis |
| Circulating FASLG levels (id: OID00792_OID20665) | 1e-524 | rs12775501 | 8 | GCST90860124 | no MR -> candidate analysis |
| Cerebrospinal fluid protein FAS levels | 7e-241 | rs6586166 | 1 | GCST90944760 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 levels | 2e-185 | rs982764 | 11 | GCST90012035 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 (analyte | 2e-161 | rs6586166 | 1 | GCST90427702 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 (analyte | 6e-133 | rs7069061 | 1 | GCST90426338 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 (analyte | 6e-124 | rs9658750 | 1 | GCST90427817 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 (analyte | 1e-98 | rs7072828 | 1 | GCST90426610 | no MR -> candidate analysis |
| FAS protein levels | 4e-73 | rs12761227 | 4 | GCST90469192 | no MR -> candidate analysis |
| FASLG protein levels | 2e-61 | rs28362318 | 7 | GCST90469191 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 6 levels ( | 4e-43 | rs7911226 | 4 | GCST90243178 | no MR -> candidate analysis |
| …and 50 more traits (see JSON) |
Top diseases by Open Targets association (of 3348 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| autoimmune lymphoproliferative syndrome type 1 | 0.94 | — | established (curated) | no MR -> candidate analysis |
| autoimmune lymphoproliferative syndrome | 0.598 | — | established (curated) | no MR -> candidate analysis |
| lymphoid neoplasm | 0.731 | — | common-variant locus | no MR -> candidate analysis |
| B-cell chronic lymphocytic leukemia | 0.609 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.725 | — | common-variant locus | MR: beta=-0.0493, p=0.141 (cis) |
| hereditary disease | 0.674 | — | established (curated) | no MR -> candidate analysis |
| lymphoid leukemia | 0.607 | — | common-variant locus | no MR -> candidate analysis |
| immunodeficiency disease | 0.559 | — | established (curated) | no MR -> candidate analysis |
Of the 8 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (FAS-associated factor 1) |
| gnomAD constraint | pLI=1, LOEUF=0.316 — LoF-INTOLERANT |
| GWAS Catalog | 93 unique SNPs / 185 rows |
| ClinVar | 558 records; 8 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 3348 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FAS’ and resolved to ‘FAS-associated factor 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 558 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 62 traits by best p-value, aggregated from 121 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P49327 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000026103/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3758063/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FAS — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FAS — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FAS%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FAS — GWAS Catalog search API (live; release not exposed)