Protein Dossier — FCER2 (Low affinity immunoglobulin epsilon Fc receptor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Forced vital capacity (FVC) |
0.0195 |
0.00644 |
0.0025 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I84 Haemorrhoids |
0.115 |
0.045 |
0.0105 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision |
0.209 |
0.0838 |
0.0125 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
19 |
7.99 |
0.0177 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
-0.339 |
0.148 |
0.0224 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0152 |
0.00679 |
0.0253 |
Wald ratio |
1 |
cis |
NA |
| Neo-neuroticism |
-0.714 |
0.321 |
0.0262 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: ankylosing spondylitis |
0.251 |
0.117 |
0.0322 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.202 |
0.0958 |
0.0347 |
Wald ratio |
1 |
cis |
NA |
| Pallidum volume |
13.2 |
6.57 |
0.0452 |
Wald ratio |
1 |
cis |
NA |
| Neo-extraversion |
0.516 |
0.259 |
0.0459 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
-0.173 |
0.0891 |
0.0521 |
Wald ratio |
1 |
cis |
NA |
| …and 85 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3291_30_2 |
CD23 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
80 association rows across 45 traits (74 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating CD209 levels |
5e-846 |
rs151212242 |
3 |
GCST90860672 |
no MR -> candidate analysis |
| FCER2/FCRL1 protein level ratio |
1e-634 |
rs12973524 |
1 |
GCST90314789 |
no MR -> candidate analysis |
| CD22/FCER2 protein level ratio |
5e-577 |
rs12973524 |
1 |
GCST90313756 |
no MR -> candidate analysis |
| FCER2/TREML2 protein level ratio |
2e-493 |
rs12973524 |
1 |
GCST90314792 |
no MR -> candidate analysis |
| FCER2/TNFRSF9 protein level ratio |
2e-479 |
rs12973524 |
1 |
GCST90314791 |
no MR -> candidate analysis |
| Circulating FCER2 levels |
3e-418 |
rs62110713 |
2 |
GCST90860667 |
no MR -> candidate analysis |
| Low affinity immunoglobulin epsilon Fc receptor levels |
2e-272 |
rs12980031 |
10 |
GCST90425675 |
no MR -> candidate analysis |
| FCER2 protein levels |
1e-194 |
rs12611038 |
7 |
GCST90469199 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein FCER2 levels |
2e-193 |
rs12980031 |
1 |
GCST90944762 |
no MR -> candidate analysis |
| CD209 antigen levels |
1e-151 |
rs4804774 |
5 |
GCST90246935 |
no MR -> candidate analysis |
| GOLM2/STC1 protein level ratio |
9e-81 |
rs12973524 |
1 |
GCST90314952 |
no MR -> candidate analysis |
| Circulating STC1 levels |
2e-78 |
rs12460997 |
2 |
GCST90860225 |
no MR -> candidate analysis |
| …and 33 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 473 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.391 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.267 |
— |
common-variant locus |
no MR -> candidate analysis |
| skin disorder |
0.22 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Low affinity immunoglobulin epsilon Fc receptor) |
| gnomAD constraint |
pLI=1.6e-10, LOEUF=1 — LoF-tolerant |
| GWAS Catalog |
117 unique SNPs / 274 rows |
| ClinVar |
74 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 473 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FCER2’ and resolved to ‘Low affinity immunoglobulin epsilon Fc receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 74 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 45 traits by best p-value, aggregated from 80 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P06734 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104921/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2940/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FCER2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FCER2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FCER2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FCER2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:36:51 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none