MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Birth weight | 0.0198 | 0.00368 | 7.13e-08 | Wald ratio | 1 | cis | 0.853 |
| Rheumatoid arthritis | -0.0545 | 0.0185 | 0.00315 | Wald ratio | 1 | cis | NA |
| Ovarian cancer | 0.039 | 0.0138 | 0.00463 | Wald ratio | 1 | cis | NA |
| High grade serous ovarian cancer | 0.0417 | 0.0164 | 0.0109 | Wald ratio | 1 | cis | NA |
| Sodium in urine | 0.00578 | 0.00262 | 0.0272 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0138 | 0.00661 | 0.0365 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: ankylosing spondylitis | -0.117 | 0.0568 | 0.0387 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.0333 | 0.0166 | 0.0456 | Wald ratio | 1 | cis | NA |
| Birth length | 0.0189 | 0.0105 | 0.0719 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | -0.0397 | 0.0225 | 0.0776 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K43 Ventral hernia | 0.0659 | 0.0374 | 0.0778 | Wald ratio | 1 | cis | NA |
| Neo-openness to experience | 0.135 | 0.0775 | 0.0817 | Wald ratio | 1 | cis | NA |
| …and 84 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
167 association rows across 126 traits (165 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating FCGR3B levels | 2e-3176 | rs1674765 | 3 | GCST90860423 | no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-b le | 2e-769 | rs6665610 | 3 | GCST90241814 | no MR -> candidate analysis |
| Circulating FCRLB levels | 2e-359 | rs61803040 | 1 | GCST90860085 | no MR -> candidate analysis |
| Total protein levels (UKB data field 30860) | 3e-306 | rs2926468 | 1 | GCST90468105 | no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-b le | 5e-303 | rs12118043 | 4 | GCST90161704 | no MR -> candidate analysis |
| Serum total protein levels | 2e-263 | rs2926468 | 6 | GCST90018976 | no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-b (a | 1e-198 | rs6665610 | 1 | GCST90424545 | no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-a/b | 4e-160 | rs6665610 | 2 | GCST90101265 | no MR -> candidate analysis |
| Circulating FCGR2B levels | 8e-134 | rs7512086 | 1 | GCST90859802 | no MR -> candidate analysis |
| FCGR3B protein levels | 2e-91 | rs545672653 | 5 | GCST90469202 | no MR -> candidate analysis |
| Aspartate aminotransferase levels (UKB data field 30650) | 2e-70 | rs61804164 | 1 | GCST90468063 | no MR -> candidate analysis |
| Serum levels of protein FCGR2B | 8e-70 | rs111528110 | 1 | GCST90088304 | no MR -> candidate analysis |
| …and 114 more traits (see JSON) |
Top diseases by Open Targets association (of 1121 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| systemic lupus erythematosus | 0.33 | — | established (curated) | no MR -> candidate analysis |
| immunoglobulin G4-related sclerosing disease | 0.533 | — | common-variant locus | no MR -> candidate analysis |
| systemic sclerosis | 0.541 | — | common-variant locus | no MR -> candidate analysis |
| cervical squamous cell carcinoma | 0.037 | — | common-variant locus | no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Low affinity immunoglobulin gamma Fc region receptor II-b) |
| gnomAD constraint | pLI=2.9e-05, LOEUF=1.08 — LoF-tolerant |
| GWAS Catalog | 195 unique SNPs / 509 rows |
| ClinVar | 73 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1121 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FCGR2B’ and resolved to ‘Low affinity immunoglobulin gamma Fc region receptor II-b’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 73 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 126 traits by best p-value, aggregated from 167 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P31994 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000072694/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4662940/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FCGR2B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FCGR2B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FCGR2B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FCGR2B — GWAS Catalog search API (live; release not exposed)