Protein Dossier — FCGR3B (Low affinity immunoglobulin gamma Fc region receptor III-B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Ulcerative colitis |
0.155 |
0.0312 |
6.91e-07 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.113 |
0.0247 |
4.25e-06 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
0.142 |
0.0374 |
1.45e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.216 |
0.0602 |
3.32e-04 |
Wald ratio |
1 |
cis |
NA |
| Age at menarche |
-0.0436 |
0.0157 |
0.0053 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.0692 |
0.0248 |
0.00531 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0393 |
0.0161 |
0.0149 |
Wald ratio |
1 |
cis |
NA |
| Haemoglobin concentration |
0.042 |
0.0179 |
0.019 |
Wald ratio |
1 |
cis |
NA |
| Total cholesterol |
0.0342 |
0.0147 |
0.0199 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
0.0901 |
0.0388 |
0.0203 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
-0.0218 |
0.00942 |
0.0205 |
Wald ratio |
1 |
cis |
NA |
| Packed cell volume |
0.125 |
0.0547 |
0.0228 |
Wald ratio |
1 |
cis |
NA |
| …and 93 more outcomes (see JSON) |
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|
|
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|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3311_27_1 |
FCG3B |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
151 association rows across 116 traits (150 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FCGR3B levels |
2e-3176 |
rs1674765 |
2 |
GCST90860423 |
no MR -> candidate analysis |
| Circulating FCRLB levels |
2e-359 |
rs61803040 |
1 |
GCST90860085 |
no MR -> candidate analysis |
| Total protein levels (UKB data field 30860) |
3e-306 |
rs2926468 |
1 |
GCST90468105 |
no MR -> candidate analysis |
| Serum total protein levels |
2e-263 |
rs2926468 |
2 |
GCST90018976 |
no MR -> candidate analysis |
| FCGR3B protein levels |
4e-108 |
rs61803007 |
7 |
GCST90453024 |
no MR -> candidate analysis |
| CLEC4A protein levels |
1e-82 |
rs200688856 |
2 |
GCST90468771 |
no MR -> candidate analysis |
| Aspartate aminotransferase levels (UKB data field 30650) |
2e-70 |
rs61804164 |
1 |
GCST90468063 |
no MR -> candidate analysis |
| Circulating CLEC4A levels |
1e-67 |
rs505415 |
1 |
GCST90860182 |
no MR -> candidate analysis |
| PDGFRA protein levels |
1e-54 |
rs61804164 |
1 |
GCST90470191 |
no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-b le |
6e-44 |
rs201117888 |
1 |
GCST90241814 |
no MR -> candidate analysis |
| Low affinity immunoglobulin gamma Fc region receptor II-b le |
1e-43 |
rs1771575 |
3 |
GCST90161704 |
no MR -> candidate analysis |
| IgG levels |
2e-42 |
rs72704050 |
2 |
GCST008576 |
no MR -> candidate analysis |
| …and 104 more traits (see JSON) |
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|
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 315 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Oral ulcer |
0.538 |
— |
common-variant locus |
no MR -> candidate analysis |
| Takayasu arteritis |
0.519 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.433 |
— |
common-variant locus |
no MR -> candidate analysis |
| Erythema nodosum |
0.43 |
— |
common-variant locus |
no MR -> candidate analysis |
| rheumatoid arthritis |
0.176 |
— |
common-variant locus |
MR: beta=0.142, p=1.45e-04 (cis) |
| limited scleroderma |
0.209 |
— |
common-variant locus |
no MR -> candidate analysis |
| hemangioma of subcutaneous tissue |
0.209 |
— |
common-variant locus |
no MR -> candidate analysis |
| anti-centromere-antibody-positive systemic scleroderma |
0.209 |
— |
common-variant locus |
no MR -> candidate analysis |
| irritable bowel syndrome |
0.206 |
— |
common-variant locus |
no MR -> candidate analysis |
| systemic lupus erythematosus |
0.039 |
— |
common-variant locus |
no MR -> candidate analysis |
| male reproductive system disorder |
0.065 |
— |
common-variant locus |
no MR -> candidate analysis |
| immunoglobulin G4-related sclerosing disease |
0.056 |
— |
common-variant locus |
no MR -> candidate analysis |
| heart disorder |
0.056 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 13 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Low affinity immunoglobulin gamma Fc region receptor III-B) |
| gnomAD constraint |
pLI=6.4e-06, LOEUF=1.09 — LoF-tolerant |
| GWAS Catalog |
198 unique SNPs / 539 rows |
| ClinVar |
82 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 315 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FCGR3B’ and resolved to ‘Low affinity immunoglobulin gamma Fc region receptor III-B’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 82 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 116 traits by best p-value, aggregated from 151 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O75015 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162747/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5842/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FCGR3B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FCGR3B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FCGR3B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FCGR3B — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:37:45 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none