Protein Dossier — FCRL3 (Fc receptor-like protein 3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Rheumatoid arthritis |
0.138 |
0.0209 |
3.76e-11 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.199 |
0.0438 |
5.72e-06 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
0.0766 |
0.0189 |
5.20e-05 |
Wald ratio |
1 |
cis |
NA |
| Ischemic stroke |
0.0965 |
0.0305 |
0.00153 |
Wald ratio |
1 |
cis |
NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis |
1.09 |
0.423 |
0.0102 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoarthritis |
0.0359 |
0.0148 |
0.0156 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0315 |
0.0133 |
0.0179 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
0.0761 |
0.0322 |
0.0181 |
Wald ratio |
1 |
cis |
NA |
| Small vessel disease |
0.157 |
0.0678 |
0.0206 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: malignant melanoma |
0.107 |
0.047 |
0.0231 |
Wald ratio |
1 |
cis |
NA |
| Body fat |
-0.0255 |
0.0118 |
0.0307 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
-0.184 |
0.0893 |
0.039 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4440_15_2 |
FCRL3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
95 association rows across 45 traits (83 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FCRL3 levels |
9e-5087 |
rs2210912 |
4 |
GCST90860213 |
no MR -> candidate analysis |
| Fc receptor-like protein 3 levels |
7e-1131 |
rs7522061 |
5 |
GCST90247566 |
no MR -> candidate analysis |
| Circulating FCRL2 levels |
2e-621 |
rs141931363 |
1 |
GCST90859715 |
no MR -> candidate analysis |
| Fc receptor-like protein 4 levels |
2e-253 |
rs59424684 |
1 |
GCST90247567 |
no MR -> candidate analysis |
| Blood protein levels |
7e-182 |
rs7522061 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Fc receptor-like protein 4 levels (FCRL4.8973.23.3) |
3e-139 |
rs200240998 |
2 |
GCST90241153 |
no MR -> candidate analysis |
| Fc receptor-like protein 3 levels (FCRL3.4440.15.2) |
1e-112 |
rs7528684 |
1 |
GCST90241152 |
no MR -> candidate analysis |
| FCRL3 protein levels |
3e-102 |
rs4453030 |
19 |
GCST90469207 |
no MR -> candidate analysis |
| Circulating FCRL5 levels |
4e-102 |
rs79495805 |
1 |
GCST90860603 |
no MR -> candidate analysis |
| Serum levels of protein FCRL4 |
5e-87 |
rs12125713 |
1 |
GCST90090419 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
2e-83 |
rs7535596 |
2 |
GCST90838667 |
no MR -> candidate analysis |
| FCRL5 protein levels |
2e-51 |
rs190935284 |
2 |
GCST90469208 |
no MR -> candidate analysis |
| …and 33 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 173 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| rheumatoid arthritis |
0.838 |
— |
common-variant locus |
MR: beta=0.138, p=3.76e-11 (cis) |
| hypothyroidism |
0.886 |
— |
common-variant locus |
MR: beta=0.0766, p=5.20e-05 (cis) |
| Graves disease |
0.865 |
— |
common-variant locus |
no MR -> candidate analysis |
| thyroid gland disorder |
0.818 |
— |
common-variant locus |
no MR -> candidate analysis |
| multiple sclerosis |
0.544 |
— |
common-variant locus |
no MR -> candidate analysis |
| thyrotoxicosis |
0.525 |
— |
common-variant locus |
MR: beta=0.199, p=5.72e-06 (cis) |
| systemic lupus erythematosus |
0.482 |
— |
common-variant locus |
no MR -> candidate analysis |
| IgA glomerulonephritis |
0.441 |
— |
common-variant locus |
no MR -> candidate analysis |
| bone Paget disease |
0.421 |
— |
common-variant locus |
no MR -> candidate analysis |
| gangrene |
0.406 |
— |
common-variant locus |
no MR -> candidate analysis |
| familial hemolytic anemia |
0.227 |
— |
common-variant locus |
no MR -> candidate analysis |
| autoimmune thyroid disease |
0.137 |
— |
common-variant locus |
no MR -> candidate analysis |
| Thromboembolism |
0.088 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian dysfunction |
0.059 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 14 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.7e-35, LOEUF=1.42 — LoF-tolerant |
| GWAS Catalog |
102 unique SNPs / 223 rows |
| ClinVar |
155 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 173 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FCRL3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 155 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 45 traits by best p-value, aggregated from 95 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q96P31 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000160856/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FCRL3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FCRL3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FCRL3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FCRL3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:38:50 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none