Protein Dossier — FETUB (Fetuin-B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypopituitarism |
0.74 |
0.277 |
0.0076 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
-1.94e+04 |
7.55e+03 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pernicious anaemia |
0.322 |
0.133 |
0.0159 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0236 |
0.01 |
0.0186 |
Wald ratio |
1 |
cis |
NA |
| LDL cholesterol |
-0.0496 |
0.0214 |
0.0206 |
Wald ratio |
1 |
cis |
NA |
| Total cholesterol |
-0.0458 |
0.021 |
0.0294 |
Wald ratio |
1 |
cis |
NA |
| IgA nephropathy |
0.647 |
0.312 |
0.0381 |
Wald ratio |
1 |
cis |
NA |
| Eye problems or disorders: Glaucoma |
-0.211 |
0.102 |
0.0393 |
Wald ratio |
1 |
cis |
NA |
| Neo-openness to experience |
0.589 |
0.288 |
0.041 |
Wald ratio |
1 |
cis |
NA |
| Age at menopause |
-0.15 |
0.0751 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.183 |
0.0916 |
0.0457 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin |
0.086 |
0.0436 |
0.0484 |
Wald ratio |
1 |
cis |
NA |
| …and 92 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3367_8_3 |
FETUB |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
43 association rows across 21 traits (43 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FETUB levels |
3e-990 |
rs114780909 |
5 |
GCST90860501 |
no MR -> candidate analysis |
| Myosin regulatory light chain 2, atrial isoform levels |
9e-447 |
rs66965282 |
2 |
GCST90248482 |
no MR -> candidate analysis |
| FETUB protein levels |
1e-224 |
rs79014333 |
4 |
GCST90469215 |
no MR -> candidate analysis |
| CRTAC1 protein levels |
1e-101 |
rs62292569 |
5 |
GCST90468870 |
no MR -> candidate analysis |
| Fetuin-B levels |
3e-97 |
rs75443068 |
6 |
GCST90137776 |
no MR -> candidate analysis |
| Fetuin-B level in Chronic kidney disease with hypertension a |
4e-85 |
rs6785067 |
1 |
GCST90237345 |
no MR -> candidate analysis |
| Circulating CRTAC1 levels |
1e-68 |
rs193281601 |
1 |
GCST90860500 |
no MR -> candidate analysis |
| F11 protein levels |
2e-62 |
rs4686434 |
2 |
GCST90469165 |
no MR -> candidate analysis |
| Serum levels of protein HRG |
7e-60 |
rs62292569 |
1 |
GCST90088856 |
no MR -> candidate analysis |
| AHSG protein levels |
7e-47 |
rs3755838 |
4 |
GCST90468263 |
no MR -> candidate analysis |
| HRG protein levels |
6e-38 |
rs142403242 |
1 |
GCST90469476 |
no MR -> candidate analysis |
| Histidine-rich glycoprotein levels |
3e-32 |
rs77190643 |
1 |
GCST90162230 |
no MR -> candidate analysis |
| …and 9 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 156 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| metabolic disease |
0.045 |
— |
common-variant locus |
no MR -> candidate analysis |
| urolithiasis |
0.043 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.043 |
— |
common-variant locus |
no MR -> candidate analysis |
| central nervous system cancer |
0.04 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.1e-09, LOEUF=1.24 — LoF-tolerant |
| GWAS Catalog |
207 unique SNPs / 558 rows |
| ClinVar |
120 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 156 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FETUB’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 120 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 21 traits by best p-value, aggregated from 43 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9UGM5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000090512/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FETUB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FETUB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FETUB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FETUB — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:39:39 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none