Protein Dossier — FGF2 (Fibroblast growth factor 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
-0.0171 |
0.0039 |
1.15e-05 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.151 |
0.0358 |
2.61e-05 |
Wald ratio |
1 |
cis |
NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0494 |
0.0141 |
4.55e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
0.567 |
0.182 |
0.00185 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0339 |
0.0117 |
0.00375 |
Wald ratio |
1 |
cis |
NA |
| Caudate volume |
27 |
9.6 |
0.00492 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
0.16 |
0.0605 |
0.0081 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.0306 |
0.012 |
0.0107 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.04 |
0.0174 |
0.0218 |
Wald ratio |
1 |
cis |
NA |
| Low grade serous ovarian cancer |
-0.203 |
0.0907 |
0.0255 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone |
0.101 |
0.0452 |
0.026 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.00976 |
0.00441 |
0.027 |
Wald ratio |
1 |
cis |
NA |
| …and 71 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3025_50_1 |
bFGF |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
63 association rows across 29 traits (54 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FGF2 levels (id: OID00954_OID20503) |
1e-2421 |
rs2922979 |
2 |
GCST90860185 |
no MR -> candidate analysis |
| Circulating FGF2 levels (id: OID00770_OID20503) |
1e-2323 |
rs2922979 |
2 |
GCST90860105 |
no MR -> candidate analysis |
| Fibroblast growth factor 2 levels |
8e-667 |
rs2922979 |
5 |
GCST90247583 |
no MR -> candidate analysis |
| FGF2 protein levels |
9e-165 |
rs41436350 |
20 |
GCST90469224 |
no MR -> candidate analysis |
| Height |
2e-96 |
rs308412 |
4 |
GCST90245848 |
no MR -> candidate analysis |
| Lymphocyte count |
8e-23 |
rs309375 |
4 |
GCST90002316 |
no MR -> candidate analysis |
| Neutrophil-to-lymphocyte ratio |
3e-19 |
rs309375 |
3 |
GCST90866310 |
no MR -> candidate analysis |
| Lymphocyte percentage of white cells |
6e-19 |
rs309375 |
1 |
GCST90002389 |
no MR -> candidate analysis |
| Lymphocyte percentage (UKB data field 30180) |
7e-19 |
rs309375 |
1 |
GCST90468083 |
no MR -> candidate analysis |
| Neutrophil percentage of white cells |
3e-17 |
rs309375 |
1 |
GCST90002399 |
no MR -> candidate analysis |
| Waist-hip ratio |
4e-17 |
rs308403 |
1 |
GCST007067 |
no MR -> candidate analysis |
| Itch intensity from mosquito bite |
3e-13 |
rs79712192 |
1 |
GCST004861 |
no MR -> candidate analysis |
| …and 17 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2488 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| atopic eczema |
0.563 |
— |
common-variant locus |
no MR -> candidate analysis |
| stroke disorder |
0.421 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.421 |
— |
common-variant locus |
no MR -> candidate analysis |
| vertebral column disorder |
0.384 |
— |
common-variant locus |
no MR -> candidate analysis |
| asthma |
0.04 |
— |
common-variant locus |
MR: beta=0.0306, p=0.0107 (cis) |
Of the 5 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Fibroblast growth factor 2) |
| gnomAD constraint |
pLI=0.00014, LOEUF=1.3 — LoF-tolerant |
| GWAS Catalog |
61 unique SNPs / 122 rows |
| ClinVar |
101 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
2 clinical annotations across 3 drugs |
phenome — Top 30 of 2488 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FGF2’ and resolved to ‘Fibroblast growth factor 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 101 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 29 traits by best p-value, aggregated from 63 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P09038 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000138685/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3107/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FGF2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FGF2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FGF2%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=FGF2 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/FGF2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:39:54 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none