Protein Dossier — FGF7 (Fibroblast growth factor 7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Fracture resulting from simple fall |
-0.0868 |
0.0385 |
0.0242 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: R55 Syncope and collapse |
0.246 |
0.112 |
0.0283 |
Wald ratio |
1 |
trans |
NA |
| Body mass index (BMI) |
0.028 |
0.0133 |
0.036 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.345 |
0.17 |
0.0427 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.247 |
0.127 |
0.0511 |
Wald ratio |
1 |
trans |
NA |
| Alzheimer’s disease |
-0.164 |
0.0873 |
0.0606 |
Wald ratio |
1 |
trans |
NA |
| Sleep duration |
-0.0195 |
0.0104 |
0.0609 |
Wald ratio |
1 |
trans |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.213 |
0.114 |
0.0621 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
0.29 |
0.165 |
0.0796 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: pernicious anaemia |
0.319 |
0.186 |
0.0867 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: osteoporosis |
-0.236 |
0.139 |
0.0888 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
-0.245 |
0.146 |
0.0926 |
Wald ratio |
1 |
trans |
NA |
| …and 68 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4487_1_1 |
FGF7 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
22 association rows across 14 traits (21 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Nontoxic multinodular goiter (PheCode 241.2) |
2e-104 |
rs4338740 |
3 |
GCST90479861 |
no MR -> candidate analysis |
| TG protein levels |
1e-36 |
rs4338740 |
1 |
GCST90470851 |
no MR -> candidate analysis |
| Circulating TSHB levels |
5e-34 |
rs10519226 |
1 |
GCST90860403 |
no MR -> candidate analysis |
| Nontoxic nodular goiter (PheCode 241) |
4e-29 |
rs4338740 |
1 |
GCST90475637 |
no MR -> candidate analysis |
| Simple and unspecified goiter (PheCode 240) |
3e-26 |
rs12592277 |
2 |
GCST90479859 |
no MR -> candidate analysis |
| Lung adenocarcinoma |
3e-14 |
rs71467682 |
2 |
GCST90297562 |
MR: beta=0.116, p=0.44 (trans) |
| Creatinine levels (UKB data field 30700) |
6e-14 |
rs28375625 |
1 |
GCST90468067 |
no MR -> candidate analysis |
| Thyroid volume |
3e-13 |
rs4338740 |
2 |
GCST001069 |
no MR -> candidate analysis |
| Circulating GAL levels |
1e-12 |
rs11639111 |
1 |
GCST90860395 |
no MR -> candidate analysis |
| Hyperthyroidism |
3e-12 |
rs4338740 |
2 |
GCST90018860 |
MR: beta=0.174, p=0.191 (trans) |
| Thyroid hormone levels |
1e-11 |
rs10519227 |
2 |
GCST001856 |
no MR -> candidate analysis |
| Hypothyroidism |
3e-10 |
rs200066768 |
2 |
GCST90627749 |
no MR -> candidate analysis |
| …and 2 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1982 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hypothyroidism |
0.719 |
— |
common-variant locus |
no MR -> candidate analysis |
| goiter |
0.681 |
— |
common-variant locus |
no MR -> candidate analysis |
| multinodular goiter |
0.649 |
— |
common-variant locus |
no MR -> candidate analysis |
| thyrotoxicosis |
0.631 |
— |
common-variant locus |
MR: beta=0.174, p=0.191 (trans) |
| nontoxic goiter |
0.564 |
— |
common-variant locus |
no MR -> candidate analysis |
| toxic multinodular goitre |
0.543 |
— |
common-variant locus |
no MR -> candidate analysis |
| basal cell carcinoma |
0.469 |
— |
common-variant locus |
MR: beta=0.213, p=0.0621 (trans) |
| asthma |
0.443 |
— |
common-variant locus |
MR: beta=0.0308, p=0.396 (trans) |
| oral cavity cancer |
0.423 |
— |
common-variant locus |
no MR -> candidate analysis |
| human papilloma virus infection |
0.423 |
— |
common-variant locus |
no MR -> candidate analysis |
| irritable bowel syndrome |
0.365 |
— |
common-variant locus |
no MR -> candidate analysis |
| hyperthyroidism |
0.333 |
— |
common-variant locus |
MR: beta=0.174, p=0.191 (trans) |
| thyroid gland disorder |
0.305 |
— |
common-variant locus |
no MR -> candidate analysis |
| Graves disease |
0.224 |
— |
common-variant locus |
no MR -> candidate analysis |
| nodular goiter |
0.211 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Fibroblast growth factor 7) |
| gnomAD constraint |
pLI=0.9, LOEUF=0.577 — LoF-INTOLERANT |
| GWAS Catalog |
52 unique SNPs / 101 rows |
| ClinVar |
47 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1982 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FGF7’ and resolved to ‘Fibroblast growth factor 7’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 47 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 14 of 14 traits by best p-value, aggregated from 22 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P21781 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000140285/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3286071/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FGF7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FGF7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FGF7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FGF7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:40:09 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none