MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Years of schooling | 0.043 | 0.0132 | 0.00115 | Wald ratio | 1 | cis | NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis | 1.55 | 0.551 | 0.00484 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | 0.155 | 0.0618 | 0.0119 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0215 | 0.0086 | 0.0123 | Wald ratio | 1 | cis | NA |
| Fasting insulin | 0.0331 | 0.0132 | 0.0124 | Wald ratio | 1 | cis | NA |
| HOMA-B | 0.0563 | 0.0232 | 0.0152 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0298 | 0.0127 | 0.0193 | Wald ratio | 1 | cis | NA |
| Pulse rate | -0.0337 | 0.0152 | 0.0266 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.119 | 0.0535 | 0.0268 | Wald ratio | 1 | cis | NA |
| Eczema | 0.125 | 0.0614 | 0.0419 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | 0.0285 | 0.0144 | 0.0486 | Wald ratio | 1 | cis | NA |
| Potassium in urine | 0.0171 | 0.00873 | 0.0504 | Wald ratio | 1 | cis | NA |
| …and 94 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
61 association rows across 40 traits (57 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Fibroblast growth factor-binding protein 3 levels | 2e-179 | rs58519543 | 1 | GCST90247596 | no MR -> candidate analysis |
| FGFBP3 protein levels | 4e-89 | rs79183014 | 4 | GCST90469232 | no MR -> candidate analysis |
| Sex hormone-binding globulin levels adjusted for BMI | 9e-54 | rs1772189 | 2 | GCST90012110 | no MR -> candidate analysis |
| Serum levels of protein FGFBP3 | 1e-51 | rs11186737 | 1 | GCST90086618 | no MR -> candidate analysis |
| Sex hormone-binding globulin levels | 7e-39 | rs1772189 | 6 | GCST90012111 | no MR -> candidate analysis |
| Blood protein levels | 6e-28 | rs11186737 | 1 | GCST006585 | no MR -> candidate analysis |
| Alkaline phosphatase (UKB data field 30610) | 3e-18 | rs1890896 | 1 | GCST90468060 | no MR -> candidate analysis |
| Liver enzyme levels (alkaline phosphatase) | 4e-18 | rs1890896 | 1 | GCST90013406 | no MR -> candidate analysis |
| Fibroblast growth factor-binding protein 3 level in Chronic | 6e-16 | rs74149314 | 1 | GCST90233133 | no MR -> candidate analysis |
| Free Cholesterol to Cholesteryl Esters in Very Large HDL rat | 6e-15 | rs11186740 | 1 | GCST90828013 | no MR -> candidate analysis |
| Height (baseline) | 7e-15 | rs68185109 | 3 | GCST90565843 | no MR -> candidate analysis |
| Height | 1e-14 | rs76264073 | 1 | GCST007841 | MR: beta=0.0139, p=0.269 (cis) |
| …and 28 more traits (see JSON) |
Top diseases by Open Targets association (of 49 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| myocardial infarction | 0.224 | — | common-variant locus | no MR -> candidate analysis |
| diabetic ketoacidosis | 0.174 | — | common-variant locus | no MR -> candidate analysis |
| lung disorder | 0.14 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.097 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.094 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.084 | — | common-variant locus | no MR -> candidate analysis |
| exostosis | 0.084 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.079 | — | common-variant locus | no MR -> candidate analysis |
| edema | 0.075 | — | common-variant locus | no MR -> candidate analysis |
| brain compression | 0.075 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.075 | — | common-variant locus | no MR -> candidate analysis |
| migraine disorder | 0.056 | — | common-variant locus | no MR -> candidate analysis |
| metabolic syndrome | 0.034 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.033, LOEUF=1.9 — LoF-tolerant |
| GWAS Catalog | 66 unique SNPs / 132 rows |
| ClinVar | 79 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 49 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FGFBP3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 79 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 40 traits by best p-value, aggregated from 61 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8TAT2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000174721/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FGFBP3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FGFBP3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FGFBP3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FGFBP3 — GWAS Catalog search API (live; release not exposed)