MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: enlarged prostate | -0.15 | 0.0583 | 0.0102 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | -0.129 | 0.0536 | 0.0158 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.164 | 0.0679 | 0.0159 | Wald ratio | 1 | cis | NA |
| ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0419 | 0.0177 | 0.0179 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0352 | 0.015 | 0.0191 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | -0.0139 | 0.00599 | 0.0199 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | -0.113 | 0.0534 | 0.035 | Wald ratio | 1 | cis | NA |
| Anorexia nervosa | -0.134 | 0.0662 | 0.0422 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | -0.597 | 0.295 | 0.0427 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: migraine | 0.0639 | 0.0317 | 0.0442 | Wald ratio | 1 | cis | NA |
| Mean cell haemoglobin | -0.0464 | 0.0235 | 0.0487 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Ankle | 0.0881 | 0.0458 | 0.0543 | Wald ratio | 1 | cis | NA |
| …and 94 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
38 association rows across 26 traits (35 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Fibrinogen-like protein 1 levels | 4e-419 | rs7815429 | 3 | GCST90247601 | no MR -> candidate analysis |
| Serum levels of protein FGL1 | 7e-128 | rs17634704 | 2 | GCST90089073 | no MR -> candidate analysis |
| Blood protein levels | 3e-70 | rs7815429 | 1 | GCST006585 | no MR -> candidate analysis |
| Circulating DPP7 levels | 3e-56 | rs2073567 | 2 | GCST90860385 | no MR -> candidate analysis |
| DPP7 protein levels | 3e-50 | rs2073566 | 3 | GCST90469035 | no MR -> candidate analysis |
| FGL1 protein levels | 2e-41 | rs34807569 | 5 | GCST90453271 | no MR -> candidate analysis |
| FGL1 protein level (protein group normalized intensity) | 3e-40 | rs7818801 | 1 | GCST90570760 | no MR -> candidate analysis |
| DPP7/SIAE protein level ratio | 9e-36 | rs693812 | 1 | GCST90314549 | no MR -> candidate analysis |
| SEMA3G protein levels | 7e-33 | rs2653414 | 1 | GCST90470571 | no MR -> candidate analysis |
| DPP7/MCFD2 protein level ratio | 7e-32 | rs693812 | 1 | GCST90314547 | no MR -> candidate analysis |
| Lung function (FEV1/FVC) | 6e-21 | rs10095395 | 2 | GCST007080 | no MR -> candidate analysis |
| CLPS protein levels | 2e-20 | rs2653414 | 1 | GCST90468786 | no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
Top diseases by Open Targets association (of 332 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| preeclampsia | 0.763 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| nicotine dependence | 0.401 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.192 | — | common-variant locus | no MR -> candidate analysis |
| cardiac arrhythmia | 0.154 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.118 | — | common-variant locus | no MR -> candidate analysis |
| hyperlipidemia | 0.105 | — | common-variant locus | no MR -> candidate analysis |
| edema | 0.107 | — | common-variant locus | no MR -> candidate analysis |
| pregnancy disorder | 0.107 | — | common-variant locus | no MR -> candidate analysis |
| Proteinuria | 0.107 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=9.5e-26, LOEUF=1.68 — LoF-tolerant |
| GWAS Catalog | 90 unique SNPs / 162 rows |
| ClinVar | 194 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 332 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FGL1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 194 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 38 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q08830 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104760/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FGL1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FGL1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FGL1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FGL1 — GWAS Catalog search API (live; release not exposed)