MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | 0.0274 | 0.00986 | 0.00547 | Wald ratio | 1 | cis | NA |
| Small vessel disease | -0.334 | 0.123 | 0.00675 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0168 | 0.00725 | 0.0204 | Wald ratio | 1 | cis | NA |
| Childhood intelligence | 0.101 | 0.0447 | 0.0244 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.027 | 0.0124 | 0.0289 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.0753 | 0.0347 | 0.0299 | Wald ratio | 1 | cis | NA |
| Microalbuminuria | 0.148 | 0.0685 | 0.0308 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | -0.0575 | 0.0274 | 0.0357 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.53 | 0.253 | 0.0363 | Wald ratio | 1 | cis | NA |
| Cigarettes smoked per day | -0.577 | 0.279 | 0.0387 | Wald ratio | 1 | cis | NA |
| Urinary albumin-to-creatinine ratio | 0.0411 | 0.02 | 0.0399 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | -0.0176 | 0.00857 | 0.0399 | Wald ratio | 1 | cis | NA |
| …and 85 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
14 association rows across 11 traits (14 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Peptidyl-prolyl cis-trans isomerase FKBP7 levels | 5e-195 | rs6704545 | 1 | GCST90248949 | no MR -> candidate analysis |
| Serum levels of protein FKBP7 | 2e-61 | rs6710856 | 1 | GCST90090609 | no MR -> candidate analysis |
| Height | 1e-53 | rs2288323 | 2 | GCST90245848 | MR: beta=0.0274, p=0.00547 (cis) |
| Peptidyl-prolyl cis-trans isomerase FKBP7 level in Chronic k | 1e-25 | rs3214535 | 1 | GCST90239293 | no MR -> candidate analysis |
| FKBP7 protein levels | 3e-21 | rs7575643 | 1 | GCST90469245 | no MR -> candidate analysis |
| Circulating FKBP7 levels | 8e-18 | rs7598228 | 1 | GCST90860694 | no MR -> candidate analysis |
| Aspartate aminotransferase levels | 6e-16 | rs71423566 | 1 | GCST90011899 | no MR -> candidate analysis |
| Height (baseline) | 3e-11 | rs71423566 | 1 | GCST90565843 | no MR -> candidate analysis |
| Appendicular lean mass | 3e-10 | rs137968292 | 1 | GCST90000025 | no MR -> candidate analysis |
| Alanine aminotransferase levels | 7e-10 | rs71423566 | 3 | GCST90019492 | no MR -> candidate analysis |
| Corneodesmosin protein levels (SomaScan ID:9288-7) | 9e-10 | rs7598228 | 1 | GCST90442727 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 57 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| atrial fibrillation | 0.623 | — | common-variant locus | MR: beta=0.0988, p=0.171 (cis) |
| alcohol drinking | 0.436 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.427 | — | common-variant locus | no MR -> candidate analysis |
| atrioventricular block | 0.356 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.139 | — | common-variant locus | no MR -> candidate analysis |
| bundle branch block | 0.107 | — | common-variant locus | no MR -> candidate analysis |
| heart disorder | 0.069 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.063 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.063 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.049 | — | common-variant locus | no MR -> candidate analysis |
| benign urinary system neoplasm | 0.049 | — | common-variant locus | no MR -> candidate analysis |
| Tachycardia | 0.047 | — | common-variant locus | no MR -> candidate analysis |
| phototoxic dermatitis | 0.043 | — | common-variant locus | no MR -> candidate analysis |
| conduction system disorder | 0.038 | — | common-variant locus | no MR -> candidate analysis |
| hypertrophic cardiomyopathy | 0.035 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8e-09, LOEUF=1.39 — LoF-tolerant |
| GWAS Catalog | 52 unique SNPs / 104 rows |
| ClinVar | 78 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 57 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FKBP7’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 78 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 11 of 11 traits by best p-value, aggregated from 14 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9Y680 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000079150/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FKBP7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FKBP7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FKBP7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FKBP7 — GWAS Catalog search API (live; release not exposed)