MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Pulse rate | 0.193 | 0.02 | 3.32e-22 | Wald ratio | 1 | cis | 0.948 |
| Systolic blood pressure automated reading | -0.0333 | 0.0116 | 0.00403 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0293 | 0.0116 | 0.0116 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Other bones | 0.102 | 0.0446 | 0.0226 | Wald ratio | 1 | cis | NA |
| Cigarettes smoked per day | -0.881 | 0.39 | 0.0238 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: arthritis (nos) | 0.233 | 0.105 | 0.0259 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone | 0.226 | 0.103 | 0.0291 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | -0.0741 | 0.0353 | 0.0357 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | -0.261 | 0.129 | 0.0433 | Wald ratio | 1 | cis | NA |
| Ferritin | 0.0858 | 0.0429 | 0.0455 | Wald ratio | 1 | cis | NA |
| Microalbuminuria | -0.187 | 0.0935 | 0.0455 | Wald ratio | 1 | cis | NA |
| Type 2 diabetes | -0.126 | 0.0632 | 0.0468 | Wald ratio | 1 | cis | NA |
| …and 98 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
57 association rows across 37 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating FLRT2 levels | 5e-1610 | rs17646457 | 3 | GCST90859710 | no MR -> candidate analysis |
| Cerebrospinal fluid protein FLRT2 levels | 3e-238 | rs17713911 | 1 | GCST90943384 | no MR -> candidate analysis |
| Leucine-rich repeat transmembrane protein FLRT2 levels | 3e-72 | rs72693232 | 2 | GCST90059963 | no MR -> candidate analysis |
| FLRT2 protein levels | 5e-44 | rs1885047 | 8 | GCST90469248 | no MR -> candidate analysis |
| Height | 6e-36 | rs11159706 | 2 | GCST90245848 | no MR -> candidate analysis |
| Smoking initiation | 8e-21 | rs112568573 | 3 | GCST90243985 | no MR -> candidate analysis |
| Vertical cup-disc ratio | 3e-18 | rs1289426 | 4 | GCST90129627 | no MR -> candidate analysis |
| Neurological blood protein biomarker levels | 3e-17 | rs2746995 | 1 | GCST008478 | no MR -> candidate analysis |
| Bone mineral density mean | 8e-16 | rs146670798 | 2 | GCST90321120 | no MR -> candidate analysis |
| Cerebellar grey matter morphology (MOSTest) | 1e-14 | rs1957792 | 1 | GCST90728589 | no MR -> candidate analysis |
| Vertical cup-disc ratio (multi-trait analysis) | 3e-12 | rs984586 | 1 | GCST009724 | no MR -> candidate analysis |
| Gamma glutamyl transferase levels | 7e-12 | rs73315633 | 1 | GCST90662899 | no MR -> candidate analysis |
| …and 25 more traits (see JSON) |
Top diseases by Open Targets association (of 163 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| atrial fibrillation | 0.723 | — | common-variant locus | no MR -> candidate analysis |
| open-angle glaucoma | 0.626 | — | common-variant locus | no MR -> candidate analysis |
| cardiac arrhythmia | 0.622 | — | common-variant locus | no MR -> candidate analysis |
| glaucoma | 0.612 | — | common-variant locus | MR: beta=-0.151, p=0.175 (cis) |
| smoking initiation | 0.612 | — | common-variant locus | no MR -> candidate analysis |
| urethral syndrome | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| psoriatic arthritis | 0.537 | — | common-variant locus | no MR -> candidate analysis |
| lobe attachment | 0.498 | — | common-variant locus | no MR -> candidate analysis |
| glomerulonephritis | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| urinary tract obstruction | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| device complication | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| cataract | 0.41 | — | common-variant locus | MR: beta=-0.159, p=0.308 (cis) |
| rheumatoid arthritis | 0.396 | — | common-variant locus | MR: beta=0.0842, p=0.323 (cis) |
| liver disorder | 0.388 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.71, LOEUF=0.578 — LoF-tolerant |
| GWAS Catalog | 68 unique SNPs / 136 rows |
| ClinVar | 116 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 163 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FLRT2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 116 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 37 traits by best p-value, aggregated from 57 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O43155 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000185070/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FLRT2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FLRT2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FLRT2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FLRT2 — GWAS Catalog search API (live; release not exposed)