MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Femoral neck bone mineral density | 0.078 | 0.0197 | 7.57e-05 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.11 | 0.0315 | 4.78e-04 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | -0.0213 | 0.00643 | 9.25e-04 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | 0.0247 | 0.00811 | 0.0023 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | 0.0678 | 0.0231 | 0.00329 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0475 | 0.0171 | 0.0055 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | -0.13 | 0.0511 | 0.011 | Wald ratio | 1 | cis | NA |
| Fractured or broken bones in last 5 years | -0.0509 | 0.0206 | 0.0135 | Wald ratio | 1 | cis | NA |
| Intracranial volume | -1.21e+04 | 4.92e+03 | 0.0136 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | -0.154 | 0.0628 | 0.0144 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.084 | 0.035 | 0.0163 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gout | 0.112 | 0.0471 | 0.0171 | Wald ratio | 1 | cis | NA |
| …and 73 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
1 association rows across 1 traits (0 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Mood disorder in prion disease | 7e-6 | rs761998 | 1 | GCST002864 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 140 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Kallmann syndrome | 0.814 | — | established (curated) | no MR -> candidate analysis |
| hypogonadotropic hypogonadism 21 with or without anosmia | 0.696 | — | established (curated) | no MR -> candidate analysis |
| bipolar disorder | 0.565 | — | common-variant locus | MR: beta=0.149, p=0.166 (cis) |
| alcohol drinking | 0.241 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.21 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.211 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.21 | — | common-variant locus | no MR -> candidate analysis |
| adverse effect | 0.203 | — | common-variant locus | no MR -> candidate analysis |
| response to stimulus | 0.203 | — | common-variant locus | no MR -> candidate analysis |
| pathological myopia | 0.182 | — | established (curated) | no MR -> candidate analysis |
| Genetic 46,XY disorder of sex development | 0.182 | — | established (curated) | no MR -> candidate analysis |
| myopia | 0.182 | — | established (curated) | no MR -> candidate analysis |
| amenorrhea | 0.182 | — | established (curated) | no MR -> candidate analysis |
| disorder of sexual differentiation | 0.182 | — | established (curated) | no MR -> candidate analysis |
| chronic venous hypertension | 0.172 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.44, LOEUF=0.599 — LoF-tolerant |
| GWAS Catalog | 8 unique SNPs / 16 rows |
| ClinVar | 150 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 140 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FLRT3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 150 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 1 of 1 traits by best p-value, aggregated from 1 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NZU0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000125848/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FLRT3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FLRT3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FLRT3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FLRT3 — GWAS Catalog search API (live; release not exposed)