MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Femoral neck bone mineral density | -0.103 | 0.0366 | 0.00481 | Wald ratio | 1 | trans | NA |
| Lumbar spine bone mineral density | -0.12 | 0.0427 | 0.00494 | Wald ratio | 1 | trans | NA |
| Height | 0.0392 | 0.014 | 0.0052 | Wald ratio | 1 | trans | NA |
| Cough on most days | 0.138 | 0.0517 | 0.00739 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | -0.156 | 0.0654 | 0.017 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R55 Syncope and collapse | -0.519 | 0.218 | 0.0173 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd | 0.324 | 0.147 | 0.0277 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.222 | 0.104 | 0.033 | Wald ratio | 1 | trans | NA |
| Neuroticism | 0.033 | 0.0165 | 0.0455 | Wald ratio | 1 | trans | NA |
| Triglycerides | -0.0454 | 0.0227 | 0.0455 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.264 | 0.133 | 0.0466 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries | -0.429 | 0.222 | 0.0538 | Wald ratio | 1 | trans | NA |
| …and 84 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
1 association rows across 1 traits (1 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Daytime nap | 2e-14 | rs2786547 | 1 | GCST011494 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 630 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| type 2 diabetes mellitus | 0.045 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.064 | — | common-variant locus | no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.34, LOEUF=0.689 — LoF-tolerant |
| GWAS Catalog | 18 unique SNPs / 36 rows |
| ClinVar | 39 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 630 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FNDC5’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 39 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 1 of 1 traits by best p-value, aggregated from 1 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8NAU1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000160097/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FNDC5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FNDC5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FNDC5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FNDC5 — GWAS Catalog search API (live; release not exposed)