MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
0.0371 |
0.00884 |
2.67e-05 |
Wald ratio |
1 |
cis |
NA |
| Weight |
0.0206 |
0.00578 |
3.63e-04 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0269 |
0.00848 |
0.00152 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.0905 |
0.0288 |
0.00168 |
Wald ratio |
1 |
cis |
NA |
| Major depressive disorder |
-0.18 |
0.0601 |
0.00272 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.0557 |
0.0194 |
0.00411 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.0137 |
0.00511 |
0.00714 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.165 |
0.0664 |
0.0129 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K35 Acute appendicitis |
0.191 |
0.0782 |
0.0144 |
Wald ratio |
1 |
cis |
NA |
| Ferritin |
-0.067 |
0.0274 |
0.0145 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.138 |
0.0638 |
0.0305 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
0.0862 |
0.0405 |
0.0331 |
Wald ratio |
1 |
cis |
NA |
| …and 87 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2841_13_2 |
sFRP-3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
46 association rows across 24 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FRZB levels |
8e-970 |
rs13009 |
3 |
GCST90859676 |
no MR -> candidate analysis |
| Secreted frizzled-related protein 3 levels |
5e-201 |
rs288326 |
7 |
GCST90249516 |
no MR -> candidate analysis |
| Height |
5e-120 |
rs1561369 |
5 |
GCST90245848 |
MR: beta=0.0371, p=2.67e-05 (cis) |
| FRZB protein levels |
2e-102 |
rs112797950 |
2 |
GCST90469269 |
no MR -> candidate analysis |
| Secreted frizzled-related protein 3 (analyte X2841.13) level |
6e-64 |
rs288326 |
1 |
GCST90425498 |
no MR -> candidate analysis |
| Serum levels of protein FRZB |
2e-55 |
rs288326 |
2 |
GCST90087651 |
no MR -> candidate analysis |
| Secreted frizzled-related protein 3 levels (FRZB.13740.51.3) |
4e-55 |
rs288326 |
2 |
GCST90242728 |
no MR -> candidate analysis |
| Heel bone mineral density |
4e-21 |
rs10206992 |
5 |
GCST007066 |
MR: beta=0.0269, p=0.00152 (cis) |
| Estimated bone mineral density |
4e-20 |
rs10206992 |
1 |
GCST90726625 |
no MR -> candidate analysis |
| Secreted frizzled-related protein 3 (analyte X13740.51) leve |
2e-19 |
rs1561369 |
1 |
GCST90422339 |
no MR -> candidate analysis |
| Vertex-wise sulcal depth |
4e-19 |
rs288326 |
1 |
GCST90095129 |
no MR -> candidate analysis |
| Neurological blood protein biomarker levels |
8e-19 |
rs288326 |
1 |
GCST008478 |
no MR -> candidate analysis |
| …and 12 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 815 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| osteoarthritis |
0.525 |
— |
established (curated) |
MR: beta=0.0863, p=0.236 (cis) |
| hypertrophic cardiomyopathy 14 |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| retinitis pigmentosa |
0.185 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.2e-12, LOEUF=1.39 — LoF-tolerant |
| GWAS Catalog |
51 unique SNPs / 102 rows |
| ClinVar |
93 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 815 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FRZB’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 93 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 24 traits by best p-value, aggregated from 46 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q92765 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162998/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FRZB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FRZB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FRZB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FRZB — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:43:06 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none