Protein Dossier — FST (Follistatin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Triglycerides |
0.82 |
0.0243 |
6.50e-250 |
Wald ratio |
1 |
trans |
0.999 |
| Non-cancer illness code self-reported: gout |
0.962 |
0.0564 |
2.86e-65 |
Wald ratio |
1 |
trans |
0.998 |
| Non-cancer illness code self-reported: high cholesterol |
0.468 |
0.0298 |
1.09e-55 |
Wald ratio |
1 |
trans |
0.999 |
| Total cholesterol |
0.366 |
0.0257 |
6.67e-46 |
Wald ratio |
1 |
trans |
0.997 |
| Urate |
0.55 |
0.0393 |
1.56e-44 |
Wald ratio |
1 |
trans |
NA |
| Alcohol intake frequency |
0.343 |
0.0259 |
7.43e-40 |
Wald ratio |
1 |
trans |
0.998 |
| Fasting glucose |
-0.229 |
0.0221 |
5.57e-25 |
Wald ratio |
1 |
trans |
0.998 |
| Crohn’s disease |
0.819 |
0.086 |
1.74e-21 |
Wald ratio |
1 |
trans |
0.998 |
| Weight |
-0.127 |
0.0155 |
2.52e-16 |
Wald ratio |
1 |
trans |
0.999 |
| Sodium in urine |
0.14 |
0.0173 |
6.66e-16 |
Wald ratio |
1 |
trans |
0.999 |
| Inflammatory bowel disease |
0.551 |
0.0712 |
1.03e-14 |
Wald ratio |
1 |
trans |
0.999 |
| Serum creatinine (eGFRcrea) |
0.0486 |
0.00657 |
1.45e-13 |
Wald ratio |
1 |
trans |
0.999 |
| …and 127 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4132_27_2 |
FST |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
141 association rows across 87 traits (120 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Bone mineral density mean |
1e-300 |
rs75580782 |
2 |
GCST90321120 |
no MR -> candidate analysis |
| MOCS2 protein levels |
3e-102 |
rs38059 |
8 |
GCST90469928 |
no MR -> candidate analysis |
| Corneal resistance factor (MTAG) |
5e-78 |
rs4865543 |
3 |
GCST90102517 |
no MR -> candidate analysis |
| Height |
1e-60 |
rs11954686 |
9 |
GCST90245848 |
MR: beta=-0.143, p=2.62e-11 (trans) |
| Corneal hysteresis |
5e-60 |
rs27323 |
1 |
GCST011391 |
no MR -> candidate analysis |
| Circulating FST levels |
1e-56 |
rs62370480 |
2 |
GCST90859779 |
no MR -> candidate analysis |
| Corneal resistance factor |
5e-53 |
rs27323 |
3 |
GCST90100568 |
no MR -> candidate analysis |
| Central corneal thickness (MTAG) |
7e-53 |
rs7737693 |
1 |
GCST90102518 |
no MR -> candidate analysis |
| FST protein levels |
4e-41 |
rs1469101 |
1 |
GCST90469273 |
no MR -> candidate analysis |
| Kidney sinus volume |
5e-35 |
rs6875756 |
3 |
GCST90668000 |
no MR -> candidate analysis |
| acne vulgaris |
4e-28 |
rs629725 |
3 |
GCST90092000 |
no MR -> candidate analysis |
| Appendicular lean mass |
1e-27 |
rs62370472 |
3 |
GCST90000025 |
no MR -> candidate analysis |
| …and 75 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2614 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.809 |
— |
common-variant locus |
no MR -> candidate analysis |
| gout |
0.689 |
— |
common-variant locus |
MR: beta=0.962, p=2.86e-65 (trans) |
| acne |
0.656 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.583 |
— |
common-variant locus |
no MR -> candidate analysis |
| hair anomaly |
0.507 |
— |
common-variant locus |
no MR -> candidate analysis |
| prostate carcinoma |
0.466 |
— |
common-variant locus |
no MR -> candidate analysis |
| orofacial cleft |
0.426 |
— |
established (curated) |
no MR -> candidate analysis |
| abdominal aortic aneurysm |
0.392 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.345 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypertensive disorder |
0.345 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of refraction |
0.348 |
— |
common-variant locus |
no MR -> candidate analysis |
| dyshidrosis |
0.346 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.339 |
— |
common-variant locus |
no MR -> candidate analysis |
| peritonitis |
0.339 |
— |
common-variant locus |
no MR -> candidate analysis |
| tibia fracture |
0.339 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1, LOEUF=0.308 — LoF-INTOLERANT |
| GWAS Catalog |
113 unique SNPs / 175 rows |
| ClinVar |
54 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2614 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘FST’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 54 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 87 traits by best p-value, aggregated from 141 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P19883 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000134363/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/FST — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FST — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FST%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FST — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:43:20 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none