MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | -0.0237 | 0.0055 | 1.69e-05 | Wald ratio | 1 | cis | NA |
| Hip osteoarthritis | 0.234 | 0.063 | 2.05e-04 | Wald ratio | 1 | cis | NA |
| Weight | -0.0155 | 0.00486 | 0.00139 | Wald ratio | 1 | cis | NA |
| Triglycerides | -0.0304 | 0.0104 | 0.00356 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gout | -0.136 | 0.053 | 0.0101 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | 0.0793 | 0.0311 | 0.0107 | Wald ratio | 1 | cis | NA |
| Glioma | -0.249 | 0.0997 | 0.0125 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.18 | 0.074 | 0.0148 | Wald ratio | 1 | cis | NA |
| Knee and hip osteoarthritis | 0.114 | 0.0478 | 0.017 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | -0.124 | 0.0521 | 0.0176 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.0106 | 0.00451 | 0.0183 | Wald ratio | 1 | cis | NA |
| Fracture resulting from simple fall | 0.0327 | 0.014 | 0.0198 | Wald ratio | 1 | cis | NA |
| …and 103 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
24 association rows across 16 traits (18 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Alpha-(1,3)-fucosyltransferase 10 levels | 1e-410 | rs62510527 | 3 | GCST90247646 | no MR -> candidate analysis |
| Alpha-(1,3)-fucosyltransferase 10 levels (FUT10.7156.2.3) | 3e-77 | rs2732317 | 2 | GCST90240231 | no MR -> candidate analysis |
| Alpha-(1,3)-fucosyltransferase 10 level in Chronic kidney di | 3e-32 | rs16880862 | 1 | GCST90238514 | no MR -> candidate analysis |
| Height | 6e-32 | rs2292748 | 2 | GCST90245848 | no MR -> candidate analysis |
| EGFL7 protein levels | 6e-29 | rs62510527 | 2 | GCST90469083 | no MR -> candidate analysis |
| Circulating EGFL7 levels | 8e-27 | rs62510527 | 2 | GCST90860323 | no MR -> candidate analysis |
| Serum levels of protein FUT10 | 3e-25 | rs13250099 | 1 | GCST90089701 | no MR -> candidate analysis |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 protein level | 3e-20 | rs2732317 | 1 | GCST90439721 | no MR -> candidate analysis |
| Circulating MFAP5 levels | 2e-11 | rs555100811 | 2 | GCST90860482 | no MR -> candidate analysis |
| Alzheimer’s disease or family history of Alzheimer’s disease | 2e-10 | rs1456752008 | 1 | GCST90624094 | no MR -> candidate analysis |
| Pulse pressure | 1e-9 | rs7845722 | 1 | GCST006626 | no MR -> candidate analysis |
| Stem cell factor levels | 1e-7 | rs1568119 | 1 | GCST004429 | no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
Top diseases by Open Targets association (of 55 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.581 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.427 | — | common-variant locus | no MR -> candidate analysis |
| peritonitis | 0.416 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.359 | — | common-variant locus | no MR -> candidate analysis |
| response to stimulus | 0.35 | — | common-variant locus | no MR -> candidate analysis |
| Thromboembolism | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| overnutrition | 0.101 | — | common-variant locus | no MR -> candidate analysis |
| response to vaccine | 0.057 | — | common-variant locus | no MR -> candidate analysis |
| cholelithiasis | 0.054 | — | common-variant locus | MR: beta=-0.0589, p=0.147 (cis) |
| schizophrenia | 0.048 | — | common-variant locus | MR: beta=-0.0182, p=0.448 (cis) |
| sinusitis | 0.048 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.045 | — | common-variant locus | no MR -> candidate analysis |
| inborn disorder of amino acid metabolism | 0.045 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.045 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Alpha-(1,3)-fucosyltransferase 10) |
| gnomAD constraint | not available |
| GWAS Catalog | 40 unique SNPs / 73 rows |
| ClinVar | 49 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 55 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FUT10’ and resolved to ‘Alpha-(1,3)-fucosyltransferase 10’ — confirm this is the intended target.gnomad — No gnomAD constraint data.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 49 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 24 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q6P4F1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000172728/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2926/ — ChEMBL_37 (released 2026-05-01)gwas: https://www.ebi.ac.uk/gwas/genes/FUT10 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FUT10%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FUT10 — GWAS Catalog search API (live; release not exposed)