Protein Dossier — FUT3 (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: asthma |
0.0289 |
0.00871 |
9.03e-04 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: malignant melanoma |
-0.138 |
0.0417 |
9.35e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.0758 |
0.024 |
0.00163 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0237 |
0.00821 |
0.00391 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.119 |
0.0421 |
0.00472 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
-0.069 |
0.0245 |
0.00484 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.188 |
0.0667 |
0.00493 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
-0.0136 |
0.00563 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M54 Dorsalgia |
-0.0622 |
0.0265 |
0.0187 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.00601 |
0.00262 |
0.022 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.0289 |
0.0128 |
0.024 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
-0.0701 |
0.0323 |
0.0303 |
Wald ratio |
1 |
cis |
NA |
| …and 72 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4548_4_2 |
Fucosyltransferase 3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
210 association rows across 134 traits (207 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Galactoside 3(4)-L-fucosyltransferase levels |
2e-739 |
rs708686 |
12 |
GCST90247666 |
no MR -> candidate analysis |
| Circulating FAM3B levels |
7e-317 |
rs708686 |
2 |
GCST90860227 |
no MR -> candidate analysis |
| FAM3B protein levels |
2e-306 |
rs708686 |
1 |
GCST90469186 |
no MR -> candidate analysis |
| Tumor biomarkers |
3e-290 |
rs3760775 |
3 |
GCST001808 |
no MR -> candidate analysis |
| Galactoside 3(4)-L-fucosyltransferase levels (FUT3.4548.4.2) |
3e-273 |
rs708686 |
4 |
GCST90241216 |
no MR -> candidate analysis |
| Serum levels of protein FUT3 |
1e-258 |
rs708686 |
2 |
GCST90088733 |
no MR -> candidate analysis |
| FUT3 or FUT5 protein levels |
6e-224 |
rs28742587 |
6 |
GCST90469280 |
no MR -> candidate analysis |
| Serum cancer antigen 19.9 levels |
2e-179 |
rs708686 |
2 |
GCST009648 |
no MR -> candidate analysis |
| Serum levels of protein FUT5 |
4e-171 |
rs3760775 |
2 |
GCST90088734 |
no MR -> candidate analysis |
| Circulating PRSS27 levels |
3e-146 |
rs708686 |
1 |
GCST90859759 |
no MR -> candidate analysis |
| Circulating CDH17 levels |
2e-139 |
rs708686 |
2 |
GCST90860687 |
no MR -> candidate analysis |
| MEP1A protein levels |
5e-138 |
rs708686 |
1 |
GCST90469887 |
no MR -> candidate analysis |
| …and 122 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 159 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| cholelithiasis |
0.91 |
— |
common-variant locus |
MR: beta=-0.0758, p=0.00163 (cis) |
| gallstones |
0.768 |
— |
common-variant locus |
no MR -> candidate analysis |
| polyp of gallbladder |
0.741 |
— |
common-variant locus |
no MR -> candidate analysis |
| Cholecystitis |
0.723 |
— |
common-variant locus |
no MR -> candidate analysis |
| idiopathic pulmonary fibrosis |
0.559 |
— |
common-variant locus |
no MR -> candidate analysis |
| viral infectious disease |
0.56 |
— |
common-variant locus |
no MR -> candidate analysis |
| COVID-19 |
0.367 |
— |
common-variant locus |
no MR -> candidate analysis |
| benign colon neoplasm |
0.306 |
— |
common-variant locus |
MR: beta=-0.0327, p=0.242 (cis) |
| response to COVID-19 vaccine |
0.298 |
— |
common-variant locus |
no MR -> candidate analysis |
| age-related macular degeneration |
0.234 |
— |
common-variant locus |
no MR -> candidate analysis |
| macular degeneration |
0.224 |
— |
common-variant locus |
no MR -> candidate analysis |
| vitamin B deficiency |
0.203 |
— |
common-variant locus |
no MR -> candidate analysis |
| vitamin B12 deficiency |
0.171 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrophic macular degeneration |
0.165 |
— |
common-variant locus |
no MR -> candidate analysis |
| wet macular degeneration |
0.165 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3) |
| gnomAD constraint |
pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged. |
| GWAS Catalog |
115 unique SNPs / 272 rows |
| ClinVar |
97 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 159 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FUT3’ and resolved to ‘3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 97 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 134 traits by best p-value, aggregated from 210 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P21217 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000171124/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3269/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FUT3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FUT3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FUT3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FUT3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:44:51 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none