Protein Dossier — FUT5 (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: asthma |
0.0357 |
0.0122 |
0.00346 |
Wald ratio |
1 |
cis |
NA |
| Urate |
-0.0276 |
0.00983 |
0.005 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.243 |
0.0894 |
0.0066 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0179 |
0.00667 |
0.00722 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.0676 |
0.0254 |
0.00772 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0298 |
0.0112 |
0.00778 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.0097 |
0.0037 |
0.00871 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.0857 |
0.0342 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
-0.0172 |
0.00794 |
0.0303 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
0.101 |
0.047 |
0.0322 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M54 Dorsalgia |
-0.0806 |
0.038 |
0.0341 |
Wald ratio |
1 |
cis |
NA |
| Fasting insulin |
-0.0119 |
0.00569 |
0.0365 |
Wald ratio |
1 |
cis |
NA |
| …and 99 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4549_78_2 |
FUT5 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
41 association rows across 25 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| FUT3 or FUT5 protein levels |
7e-284 |
rs8101625 |
6 |
GCST90469280 |
no MR -> candidate analysis |
| Circulating FUT3_FUT5 levels |
2e-269 |
rs8101625 |
1 |
GCST90860673 |
no MR -> candidate analysis |
| Alpha-(1,3)-fucosyltransferase 5 levels |
2e-189 |
rs8101625 |
7 |
GCST90247647 |
no MR -> candidate analysis |
| Heart rate variability (corrected root mean square of succes |
6e-56 |
rs35952442 |
1 |
GCST90281264 |
no MR -> candidate analysis |
| Alpha-(1,3)-fucosyltransferase 5 levels (FUT5.4549.78.2) |
9e-50 |
rs4807054 |
1 |
GCST90240232 |
no MR -> candidate analysis |
| Heart rate variability (root mean square of successive diffe |
4e-42 |
rs201334918 |
1 |
GCST90281263 |
no MR -> candidate analysis |
| LEG1 protein levels |
1e-39 |
rs180852977 |
2 |
GCST90469753 |
no MR -> candidate analysis |
| Circulating LGALS3 levels |
9e-26 |
rs113243450 |
3 |
GCST90859927 |
no MR -> candidate analysis |
| Galactoside 3(4)-L-fucosyltransferase levels |
7e-25 |
rs113149612 |
3 |
GCST90162115 |
no MR -> candidate analysis |
| Serum levels of protein FUT5 |
2e-18 |
rs778977 |
1 |
GCST90088734 |
no MR -> candidate analysis |
| LGALS3 protein levels |
2e-17 |
rs113243450 |
1 |
GCST90469761 |
no MR -> candidate analysis |
| Heart rate variability traits (SDNN) |
7e-16 |
rs12982903 |
1 |
GCST004714 |
no MR -> candidate analysis |
| …and 13 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 63 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| polyp of gallbladder |
0.337 |
— |
common-variant locus |
no MR -> candidate analysis |
| vitamin B12 deficiency |
0.29 |
— |
common-variant locus |
no MR -> candidate analysis |
| deficiency anemia |
0.277 |
— |
common-variant locus |
no MR -> candidate analysis |
| megaloblastic anemia |
0.277 |
— |
common-variant locus |
no MR -> candidate analysis |
| cholelithiasis |
0.242 |
— |
common-variant locus |
MR: beta=-0.0857, p=0.0124 (cis) |
| benign colon neoplasm |
0.188 |
— |
common-variant locus |
no MR -> candidate analysis |
| COVID-19 |
0.15 |
— |
common-variant locus |
no MR -> candidate analysis |
| response to COVID-19 vaccine |
0.125 |
— |
common-variant locus |
no MR -> candidate analysis |
| age-related macular degeneration |
0.085 |
— |
common-variant locus |
no MR -> candidate analysis |
| macular degeneration |
0.076 |
— |
common-variant locus |
no MR -> candidate analysis |
| vitamin B deficiency |
0.075 |
— |
common-variant locus |
no MR -> candidate analysis |
| wet macular degeneration |
0.059 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrophic macular degeneration |
0.059 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 13 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5) |
| gnomAD constraint |
pLI=0.15, LOEUF=5.99 — LoF-tolerant |
| GWAS Catalog |
115 unique SNPs / 270 rows |
| ClinVar |
123 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 63 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FUT5’ and resolved to ‘4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 123 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 25 traits by best p-value, aggregated from 41 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q11128 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000130383/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3146/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FUT5 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FUT5 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FUT5%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FUT5 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T02:45:09 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none