MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Height | -0.0124 | 0.00343 | 3.05e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: sleep apnoea | 0.13 | 0.0449 | 0.00384 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | -0.0695 | 0.0254 | 0.0062 | Wald ratio | 1 | cis | NA |
| Birth weight | -0.0114 | 0.00419 | 0.00639 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.00739 | 0.00283 | 0.00908 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | -0.0507 | 0.0239 | 0.0342 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: malignant melanoma | -0.0727 | 0.0346 | 0.0356 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) | 0.071 | 0.0346 | 0.0405 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.0268 | 0.0132 | 0.0417 | Wald ratio | 1 | cis | NA |
| Years of schooling | -0.00953 | 0.00477 | 0.0455 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: retinal detachment | 0.0877 | 0.0453 | 0.0528 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: polio or poliomyelitis | 0.17 | 0.0922 | 0.0644 | Wald ratio | 1 | cis | NA |
| …and 79 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
266 association rows across 86 traits (234 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| FUT8 protein levels | 6e-248 | rs117550570 | 14 | GCST90469281 | no MR -> candidate analysis |
| Percentage of core-fucosylation of trigalactosylated structu | 6e-184 | rs2411815 | 2 | GCST90668789 | no MR -> candidate analysis |
| N-glycosylation (multivariate analysis) | 9e-164 | rs1953415 | 1 | GCST90671969 | no MR -> candidate analysis |
| Alpha-(1,6)-fucosyltransferase levels | 2e-111 | rs6573606 | 3 | GCST90059964 | no MR -> candidate analysis |
| Cerebrospinal fluid protein FUT8 levels | 9e-82 | rs72716421 | 1 | GCST90943396 | no MR -> candidate analysis |
| Advanced glycosylation end product-specific receptor, solubl | 2e-63 | rs1958560 | 2 | GCST90246455 | no MR -> candidate analysis |
| Height | 6e-49 | rs2064695 | 2 | GCST90245848 | MR: beta=-0.0124, p=3.05e-04 (cis) |
| Transferrin N-glycan 20 levels | 3e-41 | rs2411815 | 2 | GCST90129364 | no MR -> candidate analysis |
| NELL1 protein levels | 8e-41 | rs11158595 | 1 | GCST90470026 | no MR -> candidate analysis |
| FCGR3B protein levels | 3e-40 | rs11158592 | 2 | GCST90469202 | no MR -> candidate analysis |
| ERBB4/NELL1 protein level ratio | 3e-39 | rs2229677 | 1 | GCST90314691 | no MR -> candidate analysis |
| N-glycan levels | 5e-37 | rs7147636 | 11 | GCST008108 | no MR -> candidate analysis |
| …and 74 more traits (see JSON) |
Top diseases by Open Targets association (of 404 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| congenital disorder of glycosylation with defective fucosylation | 0.811 | — | established (curated) | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.688 | — | common-variant locus | no MR -> candidate analysis |
| hereditary disease | 0.682 | — | established (curated) | no MR -> candidate analysis |
| gout | 0.63 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.049 | — | common-variant locus | no MR -> candidate analysis |
| myopathy | 0.561 | — | common-variant locus | MR: beta=0.132, p=0.465 (cis) |
| Genu varum | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| Genu valgum | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| bladder calculus | 0.473 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.307 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.319 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.319 | — | common-variant locus | no MR -> candidate analysis |
| glomerulonephritis | 0.307 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.303 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Alpha-(1,6)-fucosyltransferase) |
| gnomAD constraint | pLI=0.34, LOEUF=0.555 — LoF-tolerant |
| GWAS Catalog | 119 unique SNPs / 275 rows |
| ClinVar | 201 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 404 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘FUT8’ and resolved to ‘Alpha-(1,6)-fucosyltransferase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 201 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 86 traits by best p-value, aggregated from 266 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9BYC5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000033170/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3596087/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/FUT8 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/FUT8 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=FUT8%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/FUT8 — GWAS Catalog search API (live; release not exposed)