MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Invasive mucinous ovarian cancer | -0.684 | 0.218 | 0.00173 | Wald ratio | 1 | cis | NA |
| Glioma | -0.652 | 0.229 | 0.0044 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.285 | 0.102 | 0.0053 | Wald ratio | 1 | cis | NA |
| Height | 0.0454 | 0.017 | 0.00766 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate | 0.251 | 0.104 | 0.0159 | Wald ratio | 1 | cis | NA |
| Caudate volume | -55.9 | 26 | 0.0314 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.191 | 0.0933 | 0.041 | Wald ratio | 1 | cis | NA |
| Eczema | -0.187 | 0.0934 | 0.045 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.0258 | 0.013 | 0.0465 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | -0.0916 | 0.0463 | 0.0477 | Wald ratio | 1 | cis | NA |
| Urate | -0.0619 | 0.0314 | 0.0492 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | -1.87 | 0.951 | 0.0493 | Wald ratio | 1 | cis | NA |
| …and 83 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
70 association rows across 49 traits (61 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Adolescent idiopathic scoliosis | 2e-53 | rs12435957 | 1 | GCST006287 | no MR -> candidate analysis |
| Polypeptide N-acetylgalactosaminyltransferase 16 levels | 3e-44 | rs12100668 | 2 | GCST90249051 | no MR -> candidate analysis |
| Educational attainment | 1e-36 | rs7150195 | 4 | GCST90105038 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 3e-31 | rs61980291 | 1 | GCST90838669 | no MR -> candidate analysis |
| Neutrophil count | 1e-25 | rs34112413 | 1 | GCST90002355 | no MR -> candidate analysis |
| Height | 2e-22 | rs2061088 | 1 | GCST90245848 | MR: beta=0.0454, p=0.00766 (cis) |
| Serum levels of protein GALNT16 | 1e-20 | rs12100668 | 1 | GCST90090384 | no MR -> candidate analysis |
| White blood cell count | 8e-17 | rs34112413 | 2 | GCST90002378 | no MR -> candidate analysis |
| High fluorescence immature platelet fraction | 5e-16 | rs77923891 | 1 | GCST90281198 | no MR -> candidate analysis |
| Immature platelet fraction | 5e-16 | rs77923891 | 1 | GCST90281200 | no MR -> candidate analysis |
| IGF 1 (UKB data field 30770) | 8e-16 | rs113574682 | 1 | GCST90468078 | no MR -> candidate analysis |
| Blood protein levels | 4e-15 | rs12100668 | 1 | GCST006585 | no MR -> candidate analysis |
| …and 37 more traits (see JSON) |
Top diseases by Open Targets association (of 75 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| physical activity | 0.657 | — | common-variant locus | no MR -> candidate analysis |
| post-traumatic stress disorder | 0.548 | — | common-variant locus | no MR -> candidate analysis |
| Intrahepatic cholestasis of pregnancy | 0.488 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.449 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary edema | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| duodenitis | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.36 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.278 | — | common-variant locus | MR: beta=0.0593, p=0.373 (cis) |
| stroke disorder | 0.139 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.139 | — | common-variant locus | no MR -> candidate analysis |
| musculoskeletal system disorder | 0.093 | — | common-variant locus | no MR -> candidate analysis |
| neurotic disorder | 0.065 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8e-06, LOEUF=0.684 — LoF-tolerant |
| GWAS Catalog | 58 unique SNPs / 112 rows |
| ClinVar | 105 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 75 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘GALNT16’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 105 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 49 traits by best p-value, aggregated from 70 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8N428 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000100626/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/GALNT16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/GALNT16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=GALNT16%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/GALNT16 — GWAS Catalog search API (live; release not exposed)